Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion Mutations
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DOI: 10.1158/1535-7163.mct-17-0256
Abstract: Patients harboring germline breast cancer susceptibility genes 1 and 2 (BRCA1/2) mutations are predisposed to developing breast, pancreatic, and ovarian cancers. BRCA2 plays a critical role in homologous recombination (HR) DNA repair and deleterious mutations… read more here.
Keywords: reversion mutations; brca2; parp inhibitor; resistance ... See more keywords
Reversion Mutations with Clinical Use of PARP Inhibitors: Many Genes, Many Versions.
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DOI: 10.1158/2159-8290.cd-17-0734
Abstract: Reversion mutations associated with PARP inhibitor resistance have been identified in tumors with RAD51C, RAD51D, and PALB2 as well as BRCA1 and BRCA2 mutations. Multiple different reversion mutations can occur in a single patient, and… read more here.
Keywords: parp inhibitors; clinical use; use parp; related article ... See more keywords
BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.
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DOI: 10.1158/2159-8290.cd-18-0715
Abstract: A key resistance mechanism to platinum-based chemotherapies and PARP inhibitors in BRCA-mutant cancers is the acquisition of BRCA reversion mutations that restore protein function. To estimate the prevalence of BRCA reversion mutations in high-grade ovarian… read more here.
Keywords: platinum; resistance; reversion mutations; reversion ... See more keywords
BRCA1/2 Reversion Mutations in Patients Treated with Poly ADP-Ribose Polymerase (PARP) Inhibitors or Platinum Agents
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DOI: 10.3390/medicina58121818
Abstract: Background: Reversion mutations in BRCA1/2, resulting in restoration of the open reading frame, have been identified as a mechanism of resistance to platinum-based chemotherapy or PARP inhibition. We sought to explore the incidence of BRCA1/2… read more here.
Keywords: reversion mutations; brca1 reversion; reversion; mutations brca1 ... See more keywords
Comprehensive Analysis of Somatic Reversion Mutations in Homologous Recombination Repair (HRR) Genes in A Large Cohort of Chinese Pan-cancer Patients
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DOI: 10.7150/jca.65650
Abstract: Purpose: Mutations leading to homologous recombination deficiency (HRD) increase the tumor sensitivity to platinum-based chemotherapy and PARP inhibitors. However, reversion mutations often develop conferring acquired drug resistance. There is still a lack of comprehensive investigation… read more here.
Keywords: reversion mutations; reversion; pan cancer; cancer ... See more keywords