Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB receptor in the mesolimbic system
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4612-y
Abstract: RationaleRepeated social defeat (RSD) increases the rewarding effects of cocaine in adolescent and adult rodents.ObjectiveThe aim of the present study was to compare the long-term effects of RSD on the conditioned rewarding effects of cocaine… read more here.
Keywords: social defeat; adult; rewarding effects; trkb receptor ... See more keywords
Insight into Glutamatergic Involvement in Rewarding Effects of Mephedrone in Rats: In Vivo and Ex Vivo Study
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DOI: 10.1007/s12035-021-02404-y
Abstract: Mephedrone is a widely used drug of abuse, exerting its effects by interacting with monoamine transporters. Although this mechanism has been widely studied heretofore, little is known about the involvement of glutamatergic transmission in mephedrone… read more here.
Keywords: rewarding effects; involvement rewarding; study; mephedrone ... See more keywords
Role of acute social stress in the rewarding effects of MDMA in adolescent mice
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DOI: 10.1016/j.bbr.2021.113348
Abstract: Drug use among adolescents is a serious problem in our society, as some individuals develop dependence and addiction. MDMA/Esctasy is one of the most typically used substances by this age group. It is well known… read more here.
Keywords: social stress; effects mdma; rewarding effects; stress ... See more keywords
Dopamine D2 receptors mediate the increase in reinstatement of the conditioned rewarding effects of cocaine induced by acute social defeat
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DOI: 10.1016/j.ejphar.2017.01.039
Abstract: Abstract Social stress modifies the activity of brain areas involved in the rewarding effects of psychostimulants, inducing neuroadaptations in the dopaminergic mesolimbic system and modifying the sensitivity of dopamine receptors. In the present study we… read more here.
Keywords: effects cocaine; cocaine induced; dopamine receptors; rewarding effects ... See more keywords
Suppression of the acute upregulation of phosphorylated-extracellular regulated kinase in ventral tegmental area by a μ-opioid receptor agonist is related to resistance to rewarding effects in a mouse model of bone cancer.
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DOI: 10.1016/j.jphs.2016.11.004
Abstract: We investigated the mechanisms underlying the suppression of the rewarding effects of opioids using the femur bone cancer (FBC) mouse model. The rewarding and antinociceptive effects of subcutaneously administered morphine and oxycodone in the FBC… read more here.
Keywords: suppression; bone cancer; rewarding effects; morphine ... See more keywords
Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist
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DOI: 10.1016/j.neuropharm.2018.01.002
Abstract: ABSTRACT Opiate dependence is a major health issue and despite the existence of opioid substitution treatment, relapse frequently occurs. Group III metabotropic glutamate (mGlu) receptors has received much attention as a putative target in ethanol… read more here.
Keywords: lsp2 9166; rewarding effects; morphine; mglu7 receptor ... See more keywords
Critical role of TLR4 in uncovering the increased rewarding effects of cocaine and ethanol induced by social defeat in male mice
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DOI: 10.1016/j.neuropharm.2020.108368
Abstract: BACKGROUND Substance use disorders and social stress are currently associated with changes in the immune system response by which they induce a proinflammatory state in neurons and glial cells that eventually modulates the reward system.… read more here.
Keywords: social defeat; rewarding effects; role; induced social ... See more keywords