Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50171-w
Abstract: How disruptions to normal cell differentiation link to tumorigenesis remains incompletely understood. Wilms tumor, an embryonal tumor associated with disrupted organogenesis, often harbors mutations in epigenetic regulators, but their role in kidney development remains unexplored.… read more here.
Keywords: enl; single cell; cell; rewiring gene ... See more keywords
A self-propagating, barcoded transposon system for the dynamic rewiring of genomic networks.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular systems biology"
DOI: 10.15252/msb.202211398
Abstract: In bacteria, natural transposon mobilization can drive adaptive genomic rearrangements. Here, we build on this capability and develop an inducible, self-propagating transposon platform for continuous genome-wide mutagenesis and the dynamic rewiring of gene networks in… read more here.
Keywords: rewiring gene; gene networks; self propagating; dynamic rewiring ... See more keywords