Gβγ recruits and activates P-Rex1 via two independent binding interfaces.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.12.089
Abstract: Gβγ marks the inner side of the plasma membrane where chemotactic GPCRs activate Rac to lead the assembly of actin filaments that push the cell to move forward. Upon dissociation from heterotrimeric Gi, Gβγ recruits… read more here.
Keywords: recruits activates; rex1; rex1 via; activates rex1 ... See more keywords
Migration, invasion, and metastasis are mediated by P-Rex1 in neuroblastoma
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1336031
Abstract: Neuroblastoma accounts for approximately 15% of pediatric cancer-related deaths despite intensive multimodal therapy. This is due, in part, to high rates of metastatic disease at diagnosis and disease relapse. A better understanding of tumor biology… read more here.
Keywords: migration; migration invasion; rex1; invasion metastasis ... See more keywords
P-Rex1 Cooperates With TGFβR2 to Drive Lung Fibroblast Migration in Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.678733
Abstract: Pulmonary fibrosis is a kind of interstitial lung disease with progressive pulmonary scar formation, leading to irreversible loss of lung functions. The TGF-β1/Smad signaling pathway plays a key role in fibrogenic processes. It is associated… read more here.
Keywords: fibrosis; rex1; migration; lung fibroblast ... See more keywords