Differential Local Stability Governs the Metamorphic Fold Switch of Bacterial Virulence Factor RfaH.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.11.014
Abstract: RfaH, a two-domain protein from a universally conserved NusG/Spt5 family of regulators, is required for the transcription and translation of long virulence and conjugation operons in many Gram-negative bacterial pathogens. Escherichia coli RfaH action is… read more here.
Keywords: rfah; differential local; virulence; local stability ... See more keywords
RfaH May Oppose Silencing by H-NS and YmoA Proteins during Transcription Elongation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00599-21
Abstract: Horizontally acquired DNA drives bacterial evolution, but its unregulated expression may harm the recipient. Xenogeneic silencers recognize foreign genes and inhibit their transcription. ABSTRACT Nucleoid-associated proteins (NAPs) silence xenogenes by blocking RNA polymerase binding to… read more here.
Keywords: elongation; ymoa proteins; transcription; rho ... See more keywords
Origins and Molecular Evolution of the NusG Paralog RfaH
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DOI: 10.1128/mbio.02717-20
Abstract: In all domains of life, NusG-like proteins make contacts similar to those of RNA polymerase and promote pause-free transcription yet may play different roles, defined by their divergent interactions with nucleic acids and accessory proteins,… read more here.
Keywords: rfah; transcription; sequence; rna polymerase ... See more keywords