Unexpected new insights into DNA clamp loaders
Sign Up to like & getrecommendations! Published in 2022 at "Bioessays"
DOI: 10.1002/bies.202200154
Abstract: Clamp loaders are pentameric AAA+ assemblies that use ATP to open and close circular DNA sliding clamps around DNA. Clamp loaders show homology in all organisms, from bacteria to human. The eukaryotic PCNA clamp is… read more here.
Keywords: clamp loaders; clamp; dna; dna clamp ... See more keywords
Experimental study on the creep behaviour of rock-filled concrete and self-compacting concrete
Sign Up to like & getrecommendations! Published in 2018 at "Construction and Building Materials"
DOI: 10.1016/j.conbuildmat.2018.07.083
Abstract: Abstract Rock-filled concrete (RFC) has become a widely used alternative for massive concrete engineering. Several studies have examined the creep behaviour of normal concrete. However, few studies have focused on the creep behaviour of RFC.… read more here.
Keywords: creep behaviour; rock filled; rfc; behaviour ... See more keywords
Investigation of setting time and compressive strength of ready-mixed concrete blended with returned fresh concrete
Sign Up to like & getrecommendations! Published in 2019 at "Construction and Building Materials"
DOI: 10.1016/j.conbuildmat.2018.11.201
Abstract: Abstract Returned fresh mix concrete (RFC) is a problem with both economic and environmental impacts. Therefore, investigators have recommended various ways to decrease the amount of RFC in manufacturing facilities. Among the most common procedures… read more here.
Keywords: compressive strength; rfc; time compressive; setting time ... See more keywords
Suitability of rock-filled concrete for constructing flexural structures
Sign Up to like & getrecommendations! Published in 2021 at "Structures"
DOI: 10.1016/j.istruc.2021.03.077
Abstract: Abstract Several studies on rock-filled concrete (RFC) have been conducted to assess its suitability as massive concrete; hence, it is necessary to evaluate the possibility of using RFC as structural elements. The crack pattern and… read more here.
Keywords: structures suitability; filled concrete; rock; rock filled ... See more keywords
Identification of expression profiles and prognostic value of RFCs in colorectal cancer
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-56361-2
Abstract: Colorectal cancer (CRC) ranks among the most prevalent cancers globally, with its incidence closely tied to DNA damage. The Replication Factor C (RFC) complexes comprises five protein subunits: RFC1, RFC2, RFC3, RFC4, and RFC5. These… read more here.
Keywords: colorectal cancer; rfc5; expression; rfc1 rfc5 ... See more keywords
Fluid-dynamics and biological features of unstable plaques: different shear stress for different plaques
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.1569
Abstract: The use of Optical Coherence Tomography (OCT) in acute coronary syndromes (ACS) allows recognizing ruptured fibrous cap (RFC) and intact fibrous cap (IFC) culprit lesions. The biological differences between them, as recently pointed out in… read more here.
Keywords: wss; fluid dynamics; shear stress; rfc ... See more keywords
Mechanism-based approach in designing patient-specific combination therapies for nonsense mutation diseases
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf216
Abstract: Abstract Premature termination codon (PTC) diseases account for ∼12% of all human disease mutations. Although there are no FDA approved treatments for increasing PTC readthrough, one readthrough inducing drug, ataluren, has conditional approval for treatment… read more here.
Keywords: ptc; combination; based approach; mutation ... See more keywords
Structure of the PCNA unloader Elg1-RFC
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adl1739
Abstract: During DNA replication, the proliferating cell nuclear antigen (PCNA) clamps are loaded onto primed sites for each Okazaki fragment synthesis by the AAA+ heteropentamer replication factor C (RFC). PCNA encircling duplex DNA is quite stable… read more here.
Keywords: unloader elg1; pcna; elg1 rfc; dna ... See more keywords
Abstract 5883: Role of major facilitative folate transporters SLC19A1 and SLC46A1 in cyclic dinucleotide transport and STING signaling
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5883
Abstract: Activation of stimulator of interferon genes (STING) activates the transcription factor pIRF3, promoting gene transcription encoding type I interferons including IFNβ that stimulate broader immune responses. Targeting the STING pathway for cancer is especially compelling… read more here.
Keywords: transport; tet rfc; adu s100; pcft ... See more keywords
Folate-Dependent Normocytic Anemia Caused By a Hypomorphic Mutation in SLC19A1 gene
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-113501
Abstract: Next generation sequencing has enabled rapid diagnosis of patients with monogenic diseases and discovery of novel disease-causing variants. However, the functional characterization of their role in disease pathogenesis still remains challenging. Reduced folate carrier (RFC)… read more here.
Keywords: anemia; folate; rfc; deletion ... See more keywords
Role of PCNA and RFC in promoting Mus81-complex activity
Sign Up to like & getrecommendations! Published in 2017 at "BMC Biology"
DOI: 10.1186/s12915-017-0429-8
Abstract: BackgroundProper DNA replication is essential for faithful transmission of the genome. However, replication stress has serious impact on the integrity of the cell, leading to stalling or collapse of replication forks, and has been determined… read more here.
Keywords: pcna; mus81; dna; stimulation ... See more keywords