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   Articles with "rfwd3" as a keyword



RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health

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recommendations! Published in 2017 at "Molecular Cell"

DOI: 10.1016/j.molcel.2017.04.021

Abstract: Summary Defects in the repair of DNA interstrand crosslinks (ICLs) are associated with the genome instability syndrome Fanconi anemia (FA). Here we report that cells with mutations in RFWD3, an E3 ubiquitin ligase that interacts… read more here.

Keywords: interstrand; rfwd3; rpa mediated; human health ... See more keywords
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Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia

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recommendations! Published in 2017 at "Journal of Clinical Investigation"

DOI: 10.1172/jci92069

Abstract: The WD40-containing E3 ubiquitin ligase RFWD3 has been recently linked to the repair of DNA damage by homologous recombination (HR). Here we have shown that an RFWD3 mutation within the WD40 domain is connected to… read more here.

Keywords: fanconi anemia; rfwd3; ubiquitin ligase; ligase rfwd3 ... See more keywords

RFWD3 Participates in the Occurrence and Development of Colorectal Cancer via E2F1 Transcriptional Regulation of BIRC5

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.675356

Abstract: Objectives: Colorectal cancer (CRC) is one of the most common human malignancies. It was reported that the alterations in the DNA damage response (DDR) pathways are emerging as novel targets for treatment across different cancer… read more here.

Keywords: rfwd3; colorectal cancer; birc5; crc ... See more keywords

Estrogen Promotes Endometrial Cancer Development by Modulating ZNF626, SLK, and RFWD3 Gene Expression and Inducing Immune Inflammatory Changes

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recommendations! Published in 2025 at "Biomedicines"

DOI: 10.3390/biomedicines13020498

Abstract: Background: Elevated estrogen has been found to contribute to the pathological development of endometrial cancer (EC), potentially through alterations in the tumor inflammatory immune microenvironment. However, the exact mechanisms underlying this process remain unclear. Methods:… read more here.

Keywords: expression; endometrial cancer; znf626 slk; rfwd3 ... See more keywords

RING finger and WD repeat domain 3 regulates proliferation and metastasis through the Wnt/β-catenin signalling pathways in hepatocellular carcinoma

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recommendations! Published in 2022 at "World Journal of Gastroenterology"

DOI: 10.3748/wjg.v28.i27.3435

Abstract: BACKGROUND Hepatocellular carcinoma (HCC) exhibits high invasiveness and mortality rates, and the molecular mechanisms of HCC have gained increasing research interest. The abnormal DNA damage response has long been recognized as one of the important… read more here.

Keywords: metastasis; rfwd3; wnt catenin; hcc ... See more keywords