IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation
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DOI: 10.1038/s41467-018-02890-0
Abstract: Epigenetic modifications affect the differentiation of T cell subsets and the pathogenesis of autoimmune diseases, but many mechanisms of epigenetic regulation of T cell differentiation are unclear. Here we show reduced expression of the transcription factor RFX1… read more here.
Keywords: rfx1; autoimmune diseases; th17 cells; differentiation ... See more keywords
RFX1 downregulation contributes to TLR4 overexpression in CD14+ monocytes via epigenetic mechanisms in coronary artery disease
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DOI: 10.1186/s13148-019-0646-9
Abstract: BackgroundToll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role in the pathogenesis of coronary artery disease (CAD). However, the mechanism remains unclear. Regulatory factor X1 (RFX1) is a critical… read more here.
Keywords: overexpression; rfx1; expression; tlr4 ... See more keywords
KMT5A downregulation participated in High Glucose-mediated EndMT via Upregulation of ENO1 Expression in Diabetic Nephropathy
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DOI: 10.7150/ijbs.62867
Abstract: Diabetic nephropathy (DN) has become the common and principal microvascular complication of diabetes that could lead to end-stage renal disease. It was reported endothelial-to-mesenchymal transition (EndMT) in glomeruli plays an important role in DN. Enolase1… read more here.
Keywords: kmt5a; eno1 expression; rfx1; high glucose ... See more keywords