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   Articles with "rg4" as a keyword



Expanding Cas12a Activity Control with an RNA G‐Quadruplex at the 5′ end of CRISPR RNA

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202411305

Abstract: Precise control of Cas12a activity is essential for the improvement of the detection limit of clinical diagnostics and the minimization of errors. This study addresses the challenge of controlling Cas12a activity, especially in the context… read more here.

Keywords: cas12a activity; control; rg4; rna ... See more keywords
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Effect of RNA sequence context and stereochemistry on G-quadruplex-RHAU53 interaction.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.09.045

Abstract: RNA G-quadruplex (rG4) structure and its association with rG4-binding proteins/peptides are important for its function. However, there is very limited study that investigates what factors are involved in rG4 that drive the rG4-protein/peptide interaction. Here… read more here.

Keywords: rg4; rna sequence; rhau53; effect rna ... See more keywords

QUADRatlas: the RNA G-quadruplex and RG4-binding proteins database

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac782

Abstract: Abstract RNA G-quadruplexes (RG4s) are non-canonical, disease-associated post-transcriptional regulators of gene expression whose functions are driven by RNA-binding proteins (RBPs). Being able to explore transcriptome-wide RG4 formation and interaction with RBPs is thus paramount to… read more here.

Keywords: rg4; quadruplex rg4; rna quadruplex; rg4s ... See more keywords

G4Atlas: a comprehensive transcriptome-wide G-quadruplex database

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac896

Abstract: Abstract RNA G-quadruplex (rG4) is a vital RNA tertiary structure motif that involves the base pairs on both Hoogsteen and Watson-Crick faces of guanines. rG4 is of great importance in the post-transcriptional regulation of gene… read more here.

Keywords: rg4; database; transcriptome wide; quadruplex database ... See more keywords

RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf039

Abstract: Abstract RNA G-quadruplexes (rG4s) are non-canonical secondary nucleic acid structures found in the transcriptome. They play crucial roles in gene regulation by interacting with G4-binding proteins (G4BPs) in cells. rG4-G4BP complexes have been associated with… read more here.

Keywords: dhx36; structure; rg4; rg4 protacs ... See more keywords
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Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts

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recommendations! Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gky861

Abstract: Abstract RNA G-quadruplexes (rG4s) are secondary structures in mRNAs known to influence RNA post-transcriptional mechanisms thereby impacting neurodegenerative disease and cancer. A detailed knowledge of rG4–protein interactions is vital to understand rG4 function. Herein, we… read more here.

Keywords: nras rna; rg4; gar domain; quadruplex ... See more keywords

RNA G-quadruplex (rG4) exacerbates cellular senescence by mediating ribosome pausing.

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recommendations! Published in 2025 at "Protein & cell"

DOI: 10.1093/procel/pwaf047

Abstract: Abstract Loss of protein homeostasis is a hallmark of cellular senescence, and ribosome pausing plays a crucial role in the collapse of proteostasis. However, our understanding of ribosome pausing in senescent cells remains limited. In… read more here.

Keywords: rg4; cellular senescence; ribosome pausing; senescent cells ... See more keywords

RNA G-Quadruplex Structures Mediate Gene Regulation in Bacteria

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recommendations! Published in 2020 at "mBio"

DOI: 10.1128/mbio.02926-19

Abstract: G-quadruplex in RNA (rG4) mediates various biological functions and cellular processes in eukaryotic organisms. However, the presence, locations, and functions of rG4 are still elusive in prokaryotes. Here, we found that rG4 is an abundant… read more here.

Keywords: range bacterial; gene regulation; bacterial species; rg4 ... See more keywords

Inhibitory Activities of Rare Ginsenoside Rg4 on Cecal Ligation and Puncture-Induced Sepsis

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms231810836

Abstract: Sepsis is an uncontrolled response to inflammatory infection and is associated with high levels of mortality and morbidity. Rg4 is a rare ginsenoside mainly found in the leaves of Panax ginseng C. A. Meyer and… read more here.

Keywords: sepsis; clp; rg4; group ... See more keywords

Ginsenoside Rg4 enhances the inductive effects of human dermal papilla spheres on hair growth via the AKT/GSK-3β/β-catenin signaling pathway.

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recommendations! Published in 2021 at "Journal of microbiology and biotechnology"

DOI: 10.4014/jmb.2101.01032

Abstract: Ginsenoside Rg4 is a rare ginsenoside that is naturally found in ginseng, and exhibits a wide range of biological activities, including antioxidant and anti-inflammatory properties, in several cell types. The purpose of this study was… read more here.

Keywords: rg4; catenin signaling; catenin; signaling pathway ... See more keywords