Talaumidin Promotes Neurite Outgrowth of Staurosporine-Differentiated RGC-5 Cells Through PI3K/Akt-Dependent Pathways.
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DOI: 10.1007/978-3-319-75402-4_79
Abstract: Talaumidin, a tetrahydrofuran neolignan isolated from the root of Aristolochia arcuata, was an interesting small molecule with neurotrophic activity in the cultured neuron. Talaumidin can promote neurite outgrowth from neurons. However, the mechanism by which… read more here.
Keywords: talaumidin promotes; talaumidin; promotes neurite; neurite outgrowth ... See more keywords
High glucose-induced ROS accumulation is a critical regulator of ERK1/2-Akt-tuberin-mTOR signalling in RGC-5 cells.
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DOI: 10.1016/j.lfs.2020.117914
Abstract: Hyperglycemia and oxidative stress are the primary stressors that elicit mitochondria specific cell stress in diabetes. Here we hypothesized that elevated level of ROS in high glucose (HG) environment, trigger mitochondrial stress by damaging mitochondrial… read more here.
Keywords: tuberin mtor; erk1 akt; akt tuberin; tuberin ... See more keywords
Neuroprotective effect of deferoxamine on N-methyl-D-aspartate-induced excitotoxicity in RGC-5 cells
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DOI: 10.1093/abbs/gmx082
Abstract: Many N-methyl-d-aspartate (NMDA) receptor antagonists have been used to treat neurodegenerative diseases induced by glutamate excitotoxicity in clinics. However, the universality of the glutamic acid neurotransmitter system makes the glutamic acid receptor blockers inefficient and… read more here.
Keywords: excitotoxicity; induced excitotoxicity; effect; excitotoxicity rgc ... See more keywords
Effect of Anti-vascular Endothelial Growth Factor Antibody on the Survival of Cultured Retinal Ganglion Cells
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DOI: 10.3341/kjo.2017.0054
Abstract: Purpose To investigate the effects of anti-vascular endothelial growth factor (VEGF) antibody on the survival of retinal ganglion cell (RGC)-5 cells differentiated with staurosporine under oxidative stress. Methods We used real-time polymerase chain reaction and… read more here.
Keywords: vegf; rgc; antibody; vegfr ... See more keywords
Scopoletin protects retinal ganglion cells 5 from high glucose-induced injury in a cellular model of diabetic retinopathy via ROS-dependent p38 and JNK signaling cascade
Sign Up to like & getrecommendations! Published in 2022 at "Central-European Journal of Immunology"
DOI: 10.5114/ceji.2022.115710
Abstract: The protective activity of scopoletin (SPT) against glucose-induced cataract has been attributed to attenuation of aldose reductase activity and oxidative stress in a rat model. The present investigation was aimed to study the protective effect… read more here.
Keywords: rgc cells; p38 jnk; glucose induced; dependent p38 ... See more keywords