Neurotrophin-conjugated nanoparticles prevent retina damage induced by oxidative stress
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2691-x
Abstract: Glaucoma and other optic neuropathies are characterized by a loss of retinal ganglion cells (RGCs), a cell layer located in the posterior eye segment. Several preclinical studies demonstrate that neurotrophins (NTs) prevent RGC loss. However,… read more here.
Keywords: drug; rgc loss; induced oxidative; oxidative stress ... See more keywords
RAGE and its ligand amyloid beta promote retinal ganglion cell loss following ischemia-reperfusion injury
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1156084
Abstract: Introduction Glaucoma is a progressive neurodegenerative disease associated with age. Accumulation of amyloid-beta (Aß) proteins in the ganglion cell layer (GCL) and subsequent retinal ganglion cell (RGC) loss is an established pathological hallmark of the… read more here.
Keywords: loss; rage; rgc loss; mice ... See more keywords