Reasons affecting the uptake of reproductive genetic carrier screening among nonpregnant reproductive‐aged women in Flanders (Belgium)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Genetic Counseling"
DOI: 10.1002/jgc4.1575
Abstract: Reproductive genetic carrier screening (RGCS) allows to identify couples who have an increased likelihood of conceiving a child affected with an autosomal recessive or X‐linked monogenic condition. Multiple studies have reported on a wide and… read more here.
Keywords: genetic carrier; rgcs; carrier screening; reasons accept ... See more keywords
Prospective parents' views on reproductive genetic carrier screening: “You know better, you do better”
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Genetic Counseling"
DOI: 10.1002/jgc4.70100
Abstract: Reproductive genetic carrier screening (RGCS) allows screening for hundreds of autosomal recessive and X‐linked conditions. Multiple clinical professional bodies recommend that RGCS be offered to all prospective parents. There is some research into attitudes to… read more here.
Keywords: genetic carrier; reproductive genetic; rgcs; prospective parents ... See more keywords
Morphological multivariate cluster analysis of murine retinal ganglion cells selectively expressing yellow fluorescent protein.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108044
Abstract: Optic neuropathies, such as glaucoma, lead to retinal ganglion cell (RGC) death. Transgenic mouse strains that express fluorescent proteins under the control of the Thy1 promoter have permitted single RGC imaging. Specifically, in one strain… read more here.
Keywords: thy1 yfp; rgcs; cluster analysis; cluster ... See more keywords
Activity of Retinal Neurons Can Be Modulated by Tunable Near-Infrared Nanoparticle Sensors.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c07663
Abstract: The vision of patients rendered blind by photoreceptor degeneration can be partially restored by exogenous stimulation of surviving retinal ganglion cells (RGCs). Whereas conventional electrical stimulation techniques have failed to produce naturalistic visual percepts, nanoparticle-based… read more here.
Keywords: nanoparticle; rgcs; near infrared; nanoparticle sensors ... See more keywords
Development and use of the Australian reproductive genetic carrier screening decision aid
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-021-00991-x
Abstract: Reproductive genetic carrier screening (RGCS) may be offered to all individuals and couples, regardless of family history or ethnicity. “Mackenzie’s Mission” (MM) is an Australian RGCS pilot study, evaluating the offer of couple-based screening for… read more here.
Keywords: rgcs; carrier screening; reproductive genetic; decision ... See more keywords
Low-frequency, low-intensity ultrasound modulates light responsiveness of mouse retinal ganglion cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/ac7d75
Abstract: Objective. Ultrasound modulates the firing activity of retinal ganglion cells (RGCs), but the effects of lower-frequency, lower-intensity ultrasound on RGCs and underlying mechanism(s) remain poorly understood. This study aims to address these questions. Approach. Multi-electrode… read more here.
Keywords: ultrasound stimulation; rgcs; ganglion cells; retinal ganglion ... See more keywords
The small molecule inhibitor PR-619 protects retinal ganglion cells against glutamate excitotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001522
Abstract: Glutamate excitotoxicity may contribute to the death of retinal ganglion cell (RGC) in glaucoma and other retinal diseases such as ischemia. Deubiquitinating enzyme (DUB) inhibitors are emerging as attractive targets for pharmacological intervention in neurodegenerative… read more here.
Keywords: glutamate excitotoxicity; excitotoxicity; rgcs; retinal ganglion ... See more keywords
MicroRNA-21-5p from induced pluripotent stem cells promotes neuroprotection of retinal ganglion cells in optic nerve crush model
Sign Up to like & getrecommendations! Published in 2025 at "BMC Ophthalmology"
DOI: 10.1186/s12886-025-04244-z
Abstract: Retinal ganglion cells (RGCs) are susceptible to degenerative conditions such as glaucoma and traumatic optic neuropathies, which lead to vision loss. MicroRNA-21-5p has demonstrated potential neuroprotective effects, but its mechanisms in optic nerve injury remain… read more here.
Keywords: culture; rgcs; model; optic nerve ... See more keywords
Serotonin regulates in a cell-type specific manner light-evoked response and synaptic activity in mouse retinal ganglion cells
Sign Up to like & getrecommendations! Published in 2025 at "Biological Research"
DOI: 10.1186/s40659-025-00594-6
Abstract: Serotonin (5-HT) is known to be synthesized and accumulated in the vertebrate retina through the 5-HT transporter, SERT. While manipulation of the serotonergic system has been shown to impact visual processing, the role of 5-HT… read more here.
Keywords: type specific; mouse retinal; rgcs; cell type ... See more keywords
Reproductive genetic carrier screening in pregnancy: improving health outcomes and expanding access
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Perinatal Medicine"
DOI: 10.1515/jpm-2024-0059
Abstract: Abstract Reproductive genetic carrier screening (RGCS) serves to screen couples for their risk of having children affected by monogenic conditions. The included conditions are mostly autosomal recessive or X-linked with infantile or early-childhood onset. Cystic… read more here.
Keywords: genetic carrier; reproductive genetic; rgcs; medicine ... See more keywords
3D Visualization of Individual Regenerating Retinal Ganglion Cell Axons Reveals Surprisingly Complex Growth Paths
Sign Up to like & getrecommendations! Published in 2017 at "eNeuro"
DOI: 10.1523/eneuro.0093-17.2017
Abstract: Abstract Retinal ganglion cells (RGCs), the sole output cells of the retina, are a heterogeneous population of neurons that project axons to visual targets in the brain. Like most CNS neurons, RGCs are considered incapable… read more here.
Keywords: visualization individual; retinal ganglion; rgcs; individual regenerating ... See more keywords