Reasons affecting the uptake of reproductive genetic carrier screening among nonpregnant reproductive‐aged women in Flanders (Belgium)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Genetic Counseling"
DOI: 10.1002/jgc4.1575
Abstract: Reproductive genetic carrier screening (RGCS) allows to identify couples who have an increased likelihood of conceiving a child affected with an autosomal recessive or X‐linked monogenic condition. Multiple studies have reported on a wide and… read more here.
Keywords: genetic carrier; rgcs; carrier screening; reasons accept ... See more keywords
Morphological multivariate cluster analysis of murine retinal ganglion cells selectively expressing yellow fluorescent protein.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108044
Abstract: Optic neuropathies, such as glaucoma, lead to retinal ganglion cell (RGC) death. Transgenic mouse strains that express fluorescent proteins under the control of the Thy1 promoter have permitted single RGC imaging. Specifically, in one strain… read more here.
Keywords: thy1 yfp; rgcs; cluster analysis; cluster ... See more keywords
Activity of Retinal Neurons Can Be Modulated by Tunable Near-Infrared Nanoparticle Sensors.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c07663
Abstract: The vision of patients rendered blind by photoreceptor degeneration can be partially restored by exogenous stimulation of surviving retinal ganglion cells (RGCs). Whereas conventional electrical stimulation techniques have failed to produce naturalistic visual percepts, nanoparticle-based… read more here.
Keywords: nanoparticle; rgcs; near infrared; nanoparticle sensors ... See more keywords
Development and use of the Australian reproductive genetic carrier screening decision aid
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-021-00991-x
Abstract: Reproductive genetic carrier screening (RGCS) may be offered to all individuals and couples, regardless of family history or ethnicity. “Mackenzie’s Mission” (MM) is an Australian RGCS pilot study, evaluating the offer of couple-based screening for… read more here.
Keywords: rgcs; carrier screening; reproductive genetic; decision ... See more keywords
Low-frequency, low-intensity ultrasound modulates light responsiveness of mouse retinal ganglion cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/ac7d75
Abstract: Objective. Ultrasound modulates the firing activity of retinal ganglion cells (RGCs), but the effects of lower-frequency, lower-intensity ultrasound on RGCs and underlying mechanism(s) remain poorly understood. This study aims to address these questions. Approach. Multi-electrode… read more here.
Keywords: ultrasound stimulation; rgcs; ganglion cells; retinal ganglion ... See more keywords
The small molecule inhibitor PR-619 protects retinal ganglion cells against glutamate excitotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001522
Abstract: Glutamate excitotoxicity may contribute to the death of retinal ganglion cell (RGC) in glaucoma and other retinal diseases such as ischemia. Deubiquitinating enzyme (DUB) inhibitors are emerging as attractive targets for pharmacological intervention in neurodegenerative… read more here.
Keywords: glutamate excitotoxicity; excitotoxicity; rgcs; retinal ganglion ... See more keywords
3D Visualization of Individual Regenerating Retinal Ganglion Cell Axons Reveals Surprisingly Complex Growth Paths
Sign Up to like & getrecommendations! Published in 2017 at "eNeuro"
DOI: 10.1523/eneuro.0093-17.2017
Abstract: Abstract Retinal ganglion cells (RGCs), the sole output cells of the retina, are a heterogeneous population of neurons that project axons to visual targets in the brain. Like most CNS neurons, RGCs are considered incapable… read more here.
Keywords: visualization individual; retinal ganglion; rgcs; individual regenerating ... See more keywords
Protection of retinal ganglion cells against optic nerve injury by induction of ischemic preconditioning.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2017.06.05
Abstract: AIM To explore if ischemic preconditioning (IPC) can enhance the survival of retinal ganglion cells (RGCs) after optic nerve axotomy. METHODS Twenty-four hours prior to retinal ischemia 60min or axotomy, IPC was applied for ten… read more here.
Keywords: ipc; retinal ganglion; rgcs; optic nerve ... See more keywords
siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative Induced Apoptosis in Retinal Ganglion Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Current molecular medicine"
DOI: 10.2174/1566524023666230511095628
Abstract: BACKGROUNDS Glaucoma is the second leading cause of blindness. Apoptosis of retinal ganglion cells (RGCs) is an important mechanism of glaucomatous optic injury. Rho kinase expression is significantly increased in apoptotic RGCs. This study aimed… read more here.
Keywords: apoptosis; rgcs; expression; rhoa ... See more keywords
Gut microbiota and derived metabolomic profiling in glaucoma with progressive neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.968992
Abstract: Glaucoma is a multifactorial, neurodegenerative disorder characterized by the loss of retinal ganglion cells (RGCs). Crosstalk between the gut microbiota and host is involved in the progression of many neurodegenerative diseases, although little is known… read more here.
Keywords: glaucoma; microbiota; gut microbiota; rgcs ... See more keywords
Elevated Pressure Increases Ca2+ Influx Through AMPA Receptors in Select Populations of Retinal Ganglion Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00162
Abstract: The predominate type of AMPA receptor expressed in the CNS is impermeable to Ca2+ (CI-AMPAR). However, some AMPA receptors are permeable to Ca2+ (CP-AMPAR) and play important roles in development, plasticity and disease. In the… read more here.
Keywords: rgc subtypes; ampa receptors; expression; elevated pressure ... See more keywords