Articles with "rgfp966" as a keyword



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RGFP966 is protective against lipopolysaccharide-induced depressive-like behaviors in mice by inhibiting neuroinflammation and microglial activation.

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Published in 2021 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2021.108259

Abstract: Depression is a prevalent mental disorder. However, its pathophysiological mechanism has still remained elusive, and a limited number of effective treatments have been presented. Recent studies have shown that neuroinflammation and microglial activation are involved… read more here.

Keywords: induced depressive; rgfp966; behaviors mice; like behaviors ... See more keywords
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Histone deacetylase 3-selective inhibitor RGFP966 ameliorates impaired glucose tolerance through β-cell protection.

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Published in 2020 at "Toxicology and applied pharmacology"

DOI: 10.1016/j.taap.2020.115189

Abstract: The potential therapeutic effect of histone deacetylase 3 (HDAC3) pharmacologic inhibition on diabetes has been focused recently. RGFP966, as a highly-selective HDAC3 inhibitor, its possible roles and underlying mechanism in the treatment of diabetes needs… read more here.

Keywords: inhibitor; rgfp966; mice; histone deacetylase ... See more keywords