FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108266
Abstract: SUMMARY Fragile X mental retardation protein (FMRP) promotes cyclic AMP (cAMP) signaling. Using an in vivo protein kinase A activity sensor (PKA-SPARK), we find that Drosophila FMRP (dFMRP) and human FMRP (hFMRP) enhance PKA activity… read more here.
Keywords: pka spark; rgg; rna binding; pka activity ... See more keywords
Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114092119
Abstract: Significance Pre-messenger RNA (pre-mRNA) splicing is a key regulatory step in gene expression. The splicing reaction is mediated by the spliceosome, a dynamic complex comprising five small nuclear ribonucleoproteins (snRNPs), which assembles onto each intron… read more here.
Keywords: spliceosome assembly; rgg; sequence specific; sequence ... See more keywords
Fast interaction dynamics of G-quadruplex and RGG-rich peptides unveiled in zero-mode waveguides
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1002
Abstract: Abstract G-quadruplexes (GQs), a non-canonical form of DNA, are receiving a huge interest as target sites for potential applications in antiviral and anticancer drug treatments. The biological functions of GQs can be controlled by specifically… read more here.
Keywords: rgg; zero mode; interaction; interaction dynamics ... See more keywords