DNA G-Quadruplex-Binding Protein Developed Using the RGG Domain of Translocated in Liposarcoma/Fused in Sarcoma Inhibits Transcription of bcl-2
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DOI: 10.1021/acsomega.3c00050
Abstract: The G-quadruplexes (G4s) in the genome are important drug targets because they regulate gene expression and the genome structure. Several small molecules that bind the G4 have been developed, but few artificial G4 binding proteins… read more here.
Keywords: binding protein; rgg domain; dna; protein ... See more keywords
Roles of the RGG Domain and RNA Recognition Motif of Nucleolin in G-Quadruplex Stabilization
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DOI: 10.1021/acsomega.9b04221
Abstract: G-quadruplexes have important biologic functions that are regulated by G-quadruplex-binding proteins. In particular, G-quadruplex structures are folded or unfolded by their binding proteins and affect transcription and other biologic functions. Here, we investigated the effect… read more here.
Keywords: nucleolin quadruplex; rgg domain; rna recognition; domain ... See more keywords