Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1811024115
Abstract: Significance Influx of calcium ions through surface membrane calcium channels that open in response to electrical signals is important for vital biological processes including generation of the heartbeat and nerve cell communication. Blocking such calcium… read more here.
Keywords: calcium channels; rgk; cav1; cav2 ... See more keywords
Molecular mechanisms and physiological relevance of RGK proteins in the heart
Sign Up to like & getrecommendations! Published in 2018 at "Acta Physiologica"
DOI: 10.1111/apha.13016
Abstract: The primary route of Ca2+ entry into cardiac myocytes is via 1,4‐dihydropyridine‐sensitive, voltage‐gated L‐type Ca2+ channels. Ca2+ influx through these channels influences duration of action potential and engages excitation‐contraction (EC) coupling in both the atria… read more here.
Keywords: mechanisms physiological; heart; rgk; physiological relevance ... See more keywords