The Association of RGS2 and Slug in the Androgen-induced Acquisition of Mesenchymal Features of Breast MDA-MB-453 Cancer Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine research"
DOI: 10.1080/07435800.2022.2036752
Abstract: BACKGROUND Epithelial-mesenchymal transition (EMT) of tumor cells is a prerequisite to cancer cell invasion and metastasis. This process involves a network of molecular alterations. Androgen receptor (AR) plays an important role in the biology of… read more here.
Keywords: cancer; dht; slug; cell ... See more keywords
Epigenetic regulation of RGS2 (Regulator of G-protein signaling 2) in chemoresistant ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2016.1277007
Abstract: Regulator of G-protein signaling 2 (RGS2) is a GTPase-activating protein functioning as an inhibitor of G-protein coupled receptors (GPCRs). RGS2 dysregulation was implicated in solid tumour development and RGS2 downregulation has been reported in prostate… read more here.
Keywords: protein; chemoresistant ovarian; rgs2; ovarian cancer ... See more keywords
Left Ventricular Dilation Resulting from the Absence of Either Rgs2 or Rgs5 Is Associated with Increased Immune Cell Infiltration in the Myocardium
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1929
Abstract: Sustained sympathoexcitation is a hallmark of heart failure, with equally sustained activation of downstream signaling pathways involving Gs- and Gi/o-coupled β-adrenergic receptors (βAR) stimulating cAMP production and PKA activation. A critical mechanism controlling G protein-mediated… read more here.
Keywords: mice; physiology; dilation; rgs2 ... See more keywords
LINC01140 Targeting miR-452-5p/RGS2 Pathway to Attenuate Breast Cancer Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/2434938
Abstract: Background LINC01140 has been known to be involved in various cancers. However, its underlying molecular mechanism in breast cancer (BC) needs further exploration. Methods The LINC01140, miR-452-5p, and RGS2 levels in BC cells and tissues… read more here.
Keywords: rgs2; breast cancer; 452 rgs2; mir 452 ... See more keywords
Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Hypertension"
DOI: 10.1161/hypertensionaha.122.20169
Abstract: Background: RGS (regulator of G protein signaling) family members catalyze the termination of G protein signaling cascades. Single nucleotide polymorphisms in the RGS2 gene in humans have been linked to hypertension, preeclampsia, and anxiety disorders.… read more here.
Keywords: rgs2; regulator protein; mice; protein signaling ... See more keywords
Morphological and biological properties of silica nanoparticles for CRTC3-siRNA delivery and downregulation of the RGS2 expression in preadipocytes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biomaterials Applications"
DOI: 10.1177/08853282211014723
Abstract: The aim of this study was to characterize the morphological properties of amorphous silica nanoparticles (SiO2 NPs), their cytotoxicity and intracellular location within Human Osteoblasts (HOB). Additionally, SiO2 NPs were explored for their effectivity as… read more here.
Keywords: crtc3 sirna; silica nanoparticles; rgs2; expression ... See more keywords
Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer"
DOI: 10.1186/s12943-025-02351-5
Abstract: This study aims to investigate the role of RGS2 in immune regulation in lung cancer (LC) and explore the regulatory relationship between RGS2 and BATF2 in modulating T cell exhaustion and tumor immune evasion. Single-cell… read more here.
Keywords: batf2; cell; tumor; rgs2 ... See more keywords
Germline deletion of Rgs2 and/or Rgs5 in male mice does not exacerbate left ventricular remodeling induced by subchronic isoproterenol infusion
Sign Up to like & getrecommendations! Published in 2025 at "Physiological Reports"
DOI: 10.14814/phy2.70178
Abstract: Sympathoexcitation is a hallmark of heart failure, with sustained β‐adrenergic receptor (βAR)‐G protein signaling activation. βAR signaling is modulated by regulator of G protein signaling (RGS) proteins. Previously, we reported that Gαi/o regulation by RGS2… read more here.
Keywords: mice; deletion; left ventricular; rgs2 ... See more keywords
Low Expression of RGS2 Promotes Poor Prognosis in High-Grade Serous Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194620
Abstract: Simple Summary Recent advances in molecular medicine have indicated G-protein coupled receptors (GPCRs) as possible therapeutic targets in ovarian cancer. The cellular effects of GPCRs are determined by regulator of G protein signaling (RGS) proteins.… read more here.
Keywords: rgs2; hgsoc; expression; expression rgs2 ... See more keywords