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   Articles with "rgs4" as a keyword



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Regulator Of G Protein Signaling-4 Modulates Short-Chain Fatty Acid-induced Cardiac Inflammation And Norepinephrine Release from Sympathetic Neurons

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5728323

Abstract: Free fatty acid receptor (FFAR)-3 (also known as GPR41) is a Gi/o protein-coupled receptor (GPCR) mediating many cellular effects of short-chain fatty acids (SCFAs) like propionate and butyrate. It inhibits cyclic 3’,5’-adenosine monophosphate (cAMP) synthesis… read more here.

Keywords: rgs4; physiology; ffar3; acid ... See more keywords
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Association Analysis Between SNPs in the Promoter Region of RGS4 and Schizophrenia in the Northern Chinese Han Population

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recommendations! Published in 2020 at "Neuropsychiatric Disease and Treatment"

DOI: 10.2147/ndt.s250282

Abstract: Background Abnormal RGS4 gene expression may cause neurotransmitter disorders, resulting in schizophrenia. The association between RGS4 and the risk of schizophrenia is controversial, and there has been little research on the SNPs in the promoter… read more here.

Keywords: snps promoter; promoter region; region rgs4; snps ... See more keywords
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βγ G-proteins, but not regulators of G-protein signaling 4, modulate opioid-induced respiratory rate depression

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recommendations! Published in 2023 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2023.1043581

Abstract: Opioid medications are the mainstay of pain management but present substantial side-effects such as respiratory depression which can be lethal with overdose. Most opioid drugs, such as fentanyl, act on opioid receptors such as the… read more here.

Keywords: respiratory depression; depression; rgs4; opioid ... See more keywords
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Targeting RGS4 Ablates Glioblastoma Proliferation

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recommendations! Published in 2020 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms21093300

Abstract: Glioblastoma (GBM) is the most common type of adult primary brain tumor with a median survival rate of less than 15 months, regardless of the current standard of care. Cellular heterogeneity, self-renewal ability and tumorigenic… read more here.

Keywords: silencing rgs4; rgs4; targeting rgs4; ablates glioblastoma ... See more keywords
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Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24076136

Abstract: The regulator of G protein signaling (RGS) proteins are crucial for the termination of G protein signals elicited by G protein-coupled receptors (GPCRs). This superfamily of cell membrane receptors, by far the largest and most… read more here.

Keywords: rgs4; heart failure; rgs proteins; protein ... See more keywords
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RGS4 deficit in prefrontal cortex contributes to the behaviors related to schizophrenia via system xc--mediated glutamatergic dysfunction in mice

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recommendations! Published in 2018 at "Theranostics"

DOI: 10.7150/thno.25189

Abstract: Rationale: Although molecular investigations of regulator of G-protein signaling 4 (RGS4) alterations in schizophrenia patients yielded partially inconsistent findings, the previous studies suggested that RGS4 is both a positional and functional candidate gene for schizophrenia… read more here.

Keywords: rgs4; rgs4 deficit; system; prefrontal cortex ... See more keywords