RGS5-TGFβ-Smad2/3 axis switches pro- to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00801-3
Abstract: Regulator-of-G-protein-signaling-5 (RGS5), a pro-apoptotic/anti-proliferative protein, is a signature molecule of tumor-associated pericytes, highly expressed in several cancers, and is associated with tumor growth and poor prognosis. Surprisingly, despite the negative influence of intrinsic RGS5 expression… read more here.
Keywords: tumor; rgs5 tgf; rgs5; tumor residing ... See more keywords
Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular research"
DOI: 10.1093/cvr/cvz268
Abstract: AIMS Genetic contribution to coronary artery disease (CAD) remains largely unillustrated. Although transcriptomic profiles have identified dozens of genes that are differentially expressed in normal and atherosclerotic vessels, whether those genes are genetically associated with… read more here.
Keywords: rgs5; endothelial cell; cad; disease ... See more keywords
Regulator of G-Protein Signaling 5 Protein Deficiency Differentially Influences Blood Pressure, Vascular and Behavioral Effects in Aged Male Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001272
Abstract: Abstract: Aging and elevated activity of the renin–angiotensin–system (RAS) are associated with hypertension, vascular and emotional behavioral abnormalities, like anxiety and depression. Many actions of the main effector hormone of the RAS, angiotensin II (Ang… read more here.
Keywords: ang; rgs5; deficiency; blood pressure ... See more keywords
miR-320a Targeting RGS5 Aggravates Atherosclerosis by Promoting Migration and Proliferation of ox-LDL–Stimulated Vascular Smooth Muscle Cells
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DOI: 10.1097/fjc.0000000000001286
Abstract: Supplemental Digital Content is Available in the Text. Abstract: MicroRNAs have been implicated in atherosclerosis (AS) progression. Here, we focused on how miR-320a affect AS progression via vascular smooth muscle cells (VSMCs). Oxidized low-density lipoproteins… read more here.
Keywords: rgs5; proliferation; expression; mir 320a ... See more keywords
GEO Database Screening Combined with In Vitro Experiments to Study the Mechanism of hsa_circ_0003570 in Infantile Hemangiomas
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DOI: 10.1155/2022/5643742
Abstract: Objective In this study, we screened out a type of differentially expressed circular RNA in infantile hemangioma (IH) cells and analyzed the mechanism in the malignant biological behavior of IH. Methods Based on the GSE98795,… read more here.
Keywords: rgs5; mir 138; hsa mir; hsa circ ... See more keywords
RGS5 decreases the proliferation of human ovarian carcinoma-derived primary endothelial cells through the MAPK/ERK signaling pathway in hypoxia
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DOI: 10.3892/or.2018.6811
Abstract: Regulator of G-protein signaling 5 (RGS5), a tissue-specific signal-regulating molecule, plays a key role in the development of the vasculature. It was recently found that RGS5 is abundantly expressed in epithelial ovarian cancer (EOC) compared… read more here.
Keywords: rgs5; rgs5 expression; expression; carcinoma derived ... See more keywords