Biotransformation of Ginsenosides Re and Rg1 into Rg2 and Rh1 by Thermostable β-Glucosidase from Thermotoga thermarum
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-017-2025-0
Abstract: The recombinant thermostable β-glucosidase from Thermotoga thermarum DSM 5069T exhibited high selectivity to catalyze the conversion of ginsenoside Re and Rg1 to the more pharmacologically active minor ginsenoside Rg2 and Rh1, respectively. At a concentration… read more here.
Keywords: glucosidase thermotoga; thermotoga thermarum; thermostable glucosidase; rg2 rh1 ... See more keywords
Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-020-01304-4
Abstract: Systemic or hepatic inflammation is caused by intraperitoneal application of lipopolysaccharide (LPS). In this study, we investigated anti-inflammatory and antioxidant properties of combination of ginsenoside-Rg2 (G-Rg2) and -Rh1 (G-Rh1) on liver function under LPS challenging.… read more here.
Keywords: liver function; rg2 rh1; rh1;
Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52537-3
Abstract: JIP3 and JIP4 (JNK-interacting proteins 3 and 4) are adaptors for cargo recruitment by dynein/dynactin and kinesin1 motors. Both are dimers that are stabilised by two sections of leucine zipper coiled coils. The N-terminal Leucine… read more here.
Keywords: lzi tandem; rh1 lzi; rh1; jip3 ... See more keywords
The V-ATPase V1 subunit A1 is required for rhodopsin anterograde trafficking in Drosophila
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-09-0546
Abstract: Synthesis and maturation of the light sensor, rhodopsin, are critical for the maintenance of light sensitivity and for photoreceptor homeostasis. In Drosophila, the main rhodopsin, Rh1, is synthesized in the endoplasmic reticulum and transported to… read more here.
Keywords: anterograde trafficking; atpase; atpase subunit; rhodopsin ... See more keywords
Ginsenoside Rh1 regulates gastric cancer cell biological behaviours and transplanted tumour growth in nude mice via the TGF‐β/Smad pathway
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13708
Abstract: Gastric cancer (GC) is one of the most prevalent malignancies of the digestive tract. Ginsenoside Rh1 was reported to exert effects on GC. The current study set out to explore the mechanism underlying Ginsenoside Rh1… read more here.
Keywords: ginsenoside rh1; tgf smad; rh1; smad pathway ... See more keywords
Complexation mechanism between 20(R, S)-ginsenoside Rh1 and serum albumin: Multi-spectroscopy, in vitro cytotoxicity, and in silico investigations.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food science"
DOI: 10.1111/1750-3841.16053
Abstract: As rare ginsenosides, 20(R, S)-ginsenoside Rh1 [20(R, S)-Rh1] are isomers and have been reported to exhibit multiple biological effects. However, the application of 20(R, S)-Rh1 is still limited due to their poor solubilities and low… read more here.
Keywords: spectroscopy; rh1; complexation mechanism; serum albumin ... See more keywords
Successful outcome of pregnancy post‐allogeneic stem cell transplant despite severe RH1 alloimmunization: A case report
Sign Up to like & getrecommendations! Published in 2023 at "British Journal of Haematology"
DOI: 10.1111/bjh.18741
Abstract: Rhesus D antigen (RH1)negative women, when exposed to RH1positive red blood cells (RBC), are at risk of developing antiRH1 antibodies. If their offspring are RH1positive, there is a risk of haemolytic disease of the fetus… read more here.
Keywords: alloimmunization; pregnancy; antibody; rh1 ... See more keywords
Functions of neuronal Synaptobrevin in the post-Golgi transport of rhodopsin in Drosophila photoreceptors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.260196
Abstract: Polarized transport is essential for constructing multiple plasma membrane domains in the cell. Drosophila photoreceptors are an excellent model system to study the mechanisms of polarized transport. Rab11 is the key factor regulating the post-Golgi… read more here.
Keywords: drosophila photoreceptors; transport; post golgi; rh1 ... See more keywords
A second visual rhodopsin gene, rh1-2, is expressed in zebrafish photoreceptors and found in other ray-finned fishes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.145953
Abstract: ABSTRACT Rhodopsin (rh1) is the visual pigment expressed in rod photoreceptors of vertebrates that is responsible for initiating the critical first step of dim-light vision. Rhodopsin is usually a single copy gene; however, we previously… read more here.
Keywords: visual rhodopsin; rhodopsin; pigment; rhodopsin gene ... See more keywords
Drosophila fabp is required for light-dependent Rhodopsin-1 clearance and photoreceptor survival
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009551
Abstract: Rhodopsins are light-detecting proteins coupled with retinal chromophores essential for visual function. Coincidentally, dysfunctional Rhodopsin homeostasis underlies retinal degeneration in humans and model organisms. Drosophila ninaEG69D mutant is one such example, where the encoded Rh1… read more here.
Keywords: fabp; dependent rhodopsin; retinal degeneration; light dependent ... See more keywords
Ginsenoside Rh1 protects human endothelial cells against lipopolysaccharide-induced inflammatory injury through inhibiting TLR2/4-mediated STAT3, NF-κB, and ER stress signaling pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.2139/ssrn.4122052
Abstract: AIM Endothelial cell (EC) dysfunction initiates atherosclerosis by inducing inflammatory cytokines and adhesion molecules. Herein, we investigated the role of ginsenoside Rh1 (Rh1) in lipopolysaccharide (LPS)-induced EC dysfunction. MAIN METHODS The inhibitory effect of Rh1… read more here.
Keywords: ginsenoside rh1; lps induced; stress signaling; signaling pathways ... See more keywords