Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A
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DOI: 10.1038/s41598-020-63611-6
Abstract: Plasmodium falciparum merozoite invasion into erythrocytes is an essential step of the blood-stage cycle, survival of parasites, and malaria pathogenesis. P. falciparum merozoite Rh5 interacting protein (PfRipr) forms a complex with Rh5 and CyRPA in… read more here.
Keywords: merozoite invasion; rh5; invasion; pfripr ... See more keywords
The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations
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DOI: 10.1186/s12936-021-03815-x
Abstract: Background The invasion of the red blood cells by Plasmodium falciparum merozoites involves the interplay of several proteins that are also targets for vaccine development. The proteins Pf Rh5- Pf Ripr- Pf CyRPA- Pf p113… read more here.
Keywords: rh5; invasion; snps identified; rh5 invasion ... See more keywords
Resurrection of the ancestral RH5 invasion ligand provides a molecular explanation for the origin of P. falciparum malaria in humans
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DOI: 10.1371/journal.pbio.3000490
Abstract: Many important infectious diseases are the result of zoonoses, in which pathogens that normally infect animals acquire mutations that enable the breaching of species barriers to permit the infection of humans. Our understanding of the… read more here.
Keywords: rh5; invasion; falciparum; falciparum malaria ... See more keywords
RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.1049065
Abstract: Background RH5 is the leading vaccine candidate for the Plasmodium falciparum blood stage and has shown impact on parasite growth in the blood in a human clinical trial. RH5 binds to Ripr and CyRPA at… read more here.
Keywords: rh5; cyrpa; combination; vaccine ... See more keywords