Inhibition of MYC attenuates tumor cell self‐renewal and promotes senescence in SMARCB1‐deficient Group 2 atypical teratoid rhabdoid tumors to suppress tumor growth in vivo
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31873
Abstract: Loss of SMARCB1 is the hallmark genetic event that characterizes rhabdoid tumors in children. Rhabdoid tumors of the brain (ATRT) occur in young children and are particularly challenging with poor long‐term survival. SMARCB1 is a… read more here.
Keywords: rhabdoid tumors; tumor; inhibition; cell ... See more keywords
Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109568
Abstract: Malignant rhabdoid tumors (MRTs) represent one of the most aggressive childhood malignancies. No effective treatment options are available, and prognosis is, therefore, dismal. Previous studies have demonstrated that tumor organoids capture the heterogeneity of patient… read more here.
Keywords: rhabdoid tumors; malignant rhabdoid; drug screening; organoid based ... See more keywords
Does Stereotactic Radiosurgery Positively Impact the Local Control of Atypical Teratoid Rhabdoid Tumors?
Sign Up to like & getrecommendations! Published in 2017 at "World neurosurgery"
DOI: 10.1016/j.wneu.2017.04.132
Abstract: BACKGROUND Atypical teratoid rhabdoid tumors (ATRTs) are rare and aggressive tumors, usually affecting patients younger than 3 years of age, that are characterized by a poor prognosis. Nowadays multimodal management, including surgery, chemotherapy and radiation… read more here.
Keywords: rhabdoid tumors; teratoid rhabdoid; atypical teratoid; management ... See more keywords
ATRT-13. DIFFERENT CELLS OF ORIGIN PAVE THE WAY FOR MOLECULAR HETEROGENEITY IN RHABDOID TUMORS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.012
Abstract: Abstract Rhabdoid tumors (RT) are rare but highly aggressive pediatric neoplasms. These tumors carry homozygous loss-of-function alterations of SMARCB1 in almost all cases with an otherwise low mutational load. RT arise at different intracranial (ATRT)… read more here.
Keywords: rhabdoid tumors; different cells; heterogeneity; atrt ... See more keywords
Neck Rhabdoid Tumors: Clinical Features and Consideration of Autologous Stem Cell Transplant.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000000829
Abstract: Extrarenal malignant rhabdoid tumors (MRT) have a poor prognosis despite aggressive therapy. Adding high-dose chemotherapy with autologous stem cell rescue (HDC-ASCR) as consolidative therapy for MRT is controversial. We describe 2 patients, age 13 years… read more here.
Keywords: rhabdoid tumors; stem cell; mrt; autologous stem ... See more keywords
The Achilles Heel of Malignant Rhabdoid Tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-0990
Abstract: Malignant rhabdoid tumors (MRT) are rare but deadly pediatric tumors characterized by mutations in the SMARCB1/SNF5/INI1/BAF47 gene. Currently, there are no targeted therapies for MRTs. In a previous issue of Cancer Research, Howard and colleagues… read more here.
Keywords: malignant rhabdoid; cancer; heel malignant; achilles heel ... See more keywords
Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-2717
Abstract: Purpose: Rhabdoid tumors are devastating pediatric cancers in need of improved therapies. We sought to identify small molecules that exhibit in vitro and in vivo efficacy against preclinical models of rhabdoid tumor. Experimental Design: We… read more here.
Keywords: rhabdoid tumor; tumor; rhabdoid tumors; hht ... See more keywords
Abstract 5182: Targeting abnormal metabolism downstream of MYC in atypical teratoid/rhabdoid tumors
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5182
Abstract: Atypical teratoid rhabdoid tumors (AT/RT) are deadly infantile brain tumors in dire need of new, targeted therapies. Recent molecular analysis revealed considerable tumor heterogeneity subdividing AT/RT into 3 distinct groups. The MYC subgroup has a… read more here.
Keywords: rhabdoid tumors; atypical teratoid; teratoid rhabdoid; myc ... See more keywords
Abstract 3933: RRM2 inhibition by COH29 is a potential therapeutic strategy for atypical teratoid rhabdoid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3933
Abstract: Introduction: Atypical teratoid rhabdoid tumors (ATRT) are a rare but aggressive malignancy in central nervous system, commonly occurring in early childhood. ATRT patients face a dismal prognosis despite aggressive therapy. Development of both effective and… read more here.
Keywords: rrm2; atrt; teratoid rhabdoid; atypical teratoid ... See more keywords
Rhabdoid Tumors Are Immunogenic and May Respond to Immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-171
Abstract: Despite their low mutational burden (TMB), human rhabdoid tumors provoke an immune response. read more here.
Keywords: may respond; immunogenic may; tumors immunogenic; rhabdoid ... See more keywords
Current and Emerging Therapeutic Approaches for Extracranial Malignant Rhabdoid Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Management and Research"
DOI: 10.2147/cmar.s289544
Abstract: Abstract Extracranial malignant rhabdoid tumors (extracranial MRT) are rare, highly aggressive malignancies affecting mainly infants and children younger than 3 years. Common anatomic sites comprise the kidneys (RTK – rhabdoid tumor of kidney) and other… read more here.
Keywords: malignant rhabdoid; extracranial mrt; therapeutic approaches; extracranial malignant ... See more keywords