RHBDF2 is correlated with immune infiltrates in hepatocellular carcinoma and may have potential as a biomarker
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13598
Abstract: Immune checkpoint inhibitors have been approved for the treatment of advanced hepatocellular carcinoma (HCC). However, immunotherapy requires the identification of suitable biomarkers to guide treatment. The gene for rhomboid 5 homolog 2 (IRHom2), which encodes… read more here.
Keywords: hepatocellular carcinoma; rhbdf2; may potential; gene ... See more keywords
The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28641-w
Abstract: Systemic metabolic syndrome significantly increases the risk of morbidity and mortality in patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). However, no effective therapeutic strategies are available, practically because our understanding of… read more here.
Keywords: liver disease; non alcoholic; rhbdf2; disease ... See more keywords
RHBDF2 governs microglial neuroinflammation during cerebral ischemia–reperfusion injury and is positively regulated by the m6A reader YTHDF1
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Medicine"
DOI: 10.1186/s10020-025-01326-y
Abstract: Neuroinflammation mediated by microglia activation is the key pathological mechanisms for cerebral ischemia–reperfusion injury (CIRI). This study investigated the role and underlying molecular mechanism of Rhomboid 5 homolog 2 (RHBDF2) in neuroinflammation during CIRI. The… read more here.
Keywords: neuroinflammation; rhbdf2; reperfusion; rhbdf2 knockdown ... See more keywords