Putative Protein Interactome of the Rhomboid Protease RHBDL4.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00680
Abstract: The physiological functions of the rhomboid-related protein 4 (RHBDL4) are emerging, but their molecular details remain unclear. Because increased expression of RHBDL4 has been clinically linked to poorer outcomes in cancer patients, this association urgently… read more here.
Keywords: rhomboid protease; rhbdl4; interactome rhomboid; protein ... See more keywords
Activity-Based Protein Profiling of RHBDL4 Reveals Proteolysis of the Enzyme and a Distinct Inhibitor Profile
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DOI: 10.1021/acschembio.4c00273
Abstract: Rhomboid proteases have fascinated scientists by virtue of their membrane-embedded active sites and proposed involvement in physiological and disease pathways. The human rhomboid protease RHBDL4 has generated particular interest due to its role in endoplasmic… read more here.
Keywords: protein profiling; activity based; rhbdl4; distinct inhibitor ... See more keywords
Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.243790
Abstract: ABSTRACT The endoplasmic reticulum (ER)-resident intramembrane rhomboid protease RHBDL4 generates metastable protein fragments and together with the ER-associated degradation (ERAD) machinery provides a clearance mechanism for aberrant and surplus proteins. However, the endogenous substrate spectrum… read more here.
Keywords: rhbdl4; protease rhbdl4; associated degradation; intramembrane ... See more keywords