Tuning the bioactivity of bone morphogenetic protein-2 with surface immobilization strategies.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.09.011
Abstract: Bone morphogenetic protein-2 (BMP-2) involved therapy is of great potential for bone regeneration. However, its clinical application is restricted due to the undesirable bioactivity and relevant complications in vivo. Immobilization of recombinant BMP-2 (rhBMP-2) is… read more here.
Keywords: rhbmp; bioactivity; immobilization; bone ... See more keywords
Immediate reconstruction of mandibular defect after treatment of medication-related osteonecrosis of the jaw (MRONJ) with rhBMP-2/ACS and miniplate: Review of 3 cases
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2019.11.038
Abstract: Highlights • The pathogenesis of MRONJ is related to repression of osteoclast mediated bone remodeling.• rhBMP-2 can stimulate not only osteoblasts but also osteoclasts and induce new bone formation.• ACS has been proved to be… read more here.
Keywords: rhbmp; mronj; rhbmp acs; treatment ... See more keywords
Exploratory meta-analysis on dose-related efficacy and complications of rhBMP-2 in anterior cervical discectomy and fusion: 1,539,021 cases from 2003 to 2017 studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Orthopaedic Translation"
DOI: 10.1016/j.jot.2020.01.002
Abstract: Abstracts Background/Objective Anterior cervical discectomy and fusion (ACDF), commonly using autogenous iliac bone graft may be limited by donor site availability, donor-site morbidity, lower fusion rate among specific patients and longer surgical time. Surgeons used… read more here.
Keywords: rhbmp; level; efficacy complications; rate ... See more keywords
Selective endocytosis of recombinant human BMPs through cell surface heparan sulfate proteoglycans in CHO cells: BMP-2 and BMP-7
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82955-1
Abstract: Cell surface heparan sulfate proteoglycan (HSPG)-mediated endocytosis results in poor yields of recombinant human bone morphogenetic proteins (rhBMPs) from CHO cell cultures. Upon incubation of rhBMP-2 and rhBMP-7 with CHO cells at 37 °C, both… read more here.
Keywords: rhbmp; cell surface; cho cells; endocytosis ... See more keywords
Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86210-5
Abstract: Autologous bone grafts are considered the gold standard grafting material for the treatment of nonunion, but in very large bone defects, traditional autograft alone is insufficient to induce repair. Recombinant human bone morphogenetic protein 2… read more here.
Keywords: rhbmp; bone grafts; scaffold; bone ... See more keywords
A novel BMP-2–loaded hydroxyapatite/beta-tricalcium phosphate microsphere/hydrogel composite for bone regeneration
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-96484-4
Abstract: Although bone morphogenetic protein (BMP) has potent osteoinductivity, the potential adverse events attributed to its burst release prevent its widespread clinical application. Therefore, there is a strong need for BMP delivery systems that maximize osteoinductivity… read more here.
Keywords: rhbmp; hydroxyapatite beta; bmp; beta tricalcium ... See more keywords
Dose-dependent Nerve Inflammatory Response to rhBMP-2 in a Rodent Spinal Nerve Model
Sign Up to like & getrecommendations! Published in 2017 at "SPINE"
DOI: 10.1097/brs.0000000000002044
Abstract: Study Design. We developed a spinal nerve root wrapping rodent model to evaluate the relationship between recombinant human bone morphogenetic protein 2 (rhBMP-2) dosage and the degree of inflammation. Objective. To investigate the direct effects… read more here.
Keywords: rhbmp; spinal nerve; mgr rhbmp; rodent spinal ... See more keywords
Incidence of Cancer in Spinal Deformity Patients Receiving High-Dose (≥40 mg) Bone Morphogenetic Protein (rhBMP-2)
Sign Up to like & getrecommendations! Published in 2017 at "SPINE"
DOI: 10.1097/brs.0000000000002232
Abstract: Study Design. Level III, Retrospective observational study. Objective. To determine if there is an increased risk of developing cancer after exposure to high-dose recombinant human bone morphogenetic protein-2 (rhBMP-2) and if risk is dose and/or… read more here.
Keywords: rhbmp; incidence; risk; dose ... See more keywords
Feasibility of Percutaneous Posterolateral Spinal Fusion With Recombinant Bone Morphogenetic Protein-2 (rhBMP-2): A Comparison With Standard Methods Using an Animal Model Study
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Spine Surgery"
DOI: 10.1097/bsd.0b013e3182aa6860
Abstract: Background Context: The clinical application of recombinant bone morphogenetic protein in spinal surgery has been shown to be safe and effective. However, its use in minimally invasive spine surgery has been limited to anterior interbody… read more here.
Keywords: rhbmp; percutaneous posterolateral; group; study ... See more keywords
Trends and Cost of Posterior Cervical Fusions With and Without Recombinant Human Bone Morphogenetic Protein-2 in the US Medicare Population
Sign Up to like & getrecommendations! Published in 2017 at "Global Spine Journal"
DOI: 10.1177/2192568217699188
Abstract: Study Design: Retrospective database review. Objective: To analyze and report the trends and cost of posterior cervical fusions (PCFs) with and without off-label recombinant human bone morphogenetic protein-2 (rhBMP-2) in the Medicare population. Methods: Patient… read more here.
Keywords: rhbmp; recombinant human; trends cost; cervical fusions ... See more keywords
Long-term outcome following additional rhBMP-7 application in revision surgery of aseptic humeral, femoral, and tibial shaft nonunion
Sign Up to like & getrecommendations! Published in 2017 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-017-1704-0
Abstract: BackgroundSurgical revision concepts for the treatment of aseptic humeral, femoral, and tibial diaphyseal nonunion were evaluated. It was analyzed if the range of time to bone healing was shorter, and if clinical and radiological long-term… read more here.
Keywords: rhbmp; revision; outcome; nonunion ... See more keywords