Constitutively active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27748
Abstract: Monoclonal antibodies (mAbs) are high value agents used for disease therapy (“biologic drugs”) or as diagnostic tools which are widely used in the healthcare sector. They are generally manufactured in mammalian cells, in particular Chinese… read more here.
Keywords: protein; constitutively active; rheb; chinese hamster ... See more keywords
Silencing of RHEB inhibits cell proliferation and promotes apoptosis in colorectal cancer cells via inhibition of the mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28984
Abstract: Colorectal cancer (CRC) is commonly known as one of the most prominent reasons for cancer‐related death in China. Ras homolog enriched in brain (RHEB) and the mammalian target activity of rapamycin (mTOR) signaling pathway were… read more here.
Keywords: cell proliferation; rheb; mtor signaling; mtor ... See more keywords
Identification of a somatic mutation in the RHEB gene through high depth and ultra-high depth next generation sequencing in a patient with Hemimegalencephaly and drug resistant Epilepsy.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2018.11.005
Abstract: Malformations of cortical development are a frequent cause of drug-resistant Epilepsy and developmental delay. Hemimegalencephaly is a Malformation of cortical development characterized by enlargement of all or a part of one cerebral hemisphere. Germline and… read more here.
Keywords: epilepsy; depth; somatic mutation; rheb ... See more keywords
Over-expressed RHEB promotes the progression of pancreatic adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119462
Abstract: AIMS Mammalian/mechanistic target of rapamycin (mTOR) is essential in the progression of pancreatic adenocarcinoma (PAAD). But the role of Ras homolog enriched in brain (RHEB), a key activator of mTORC1, is unclear in this disease.… read more here.
Keywords: paad; pancreatic adenocarcinoma; expressed rheb; rheb ... See more keywords
Development of an RHEB-Targeting Peptide To Inhibit mTORC1 Kinase Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01865
Abstract: In cancer, the mechanistic/mammalian target of rapamycin complex-1 (mTORC1) is hyperactivated to promote survival under adverse conditions. The kinase activity of mTORC1 is activated by small-GTPase RHEB-GTP. Therefore, a new modality to inhibit mTORC1 activity… read more here.
Keywords: inhibit mtorc1; kinase activity; mtorc1; rheb ... See more keywords
The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
Sign Up to like & getrecommendations! Published in 2024 at "Cell Research"
DOI: 10.1038/s41422-024-00938-z
Abstract: Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1) to coordinate signaling cascades in response to nutrients and growth factors. Despite extensive studies,… read more here.
Keywords: protein; proximity labeling; labeling system; rheb ... See more keywords
Abstract A10: Exploring the interplay between the purinosome, a multienzyme, purine biosynthetic machine, and the Rheb-mTORC1 signaling axis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.pi3k-mtor18-a10
Abstract: Pharmacologic agents that interfere with nucleotide metabolism constitute an important class of anticancer agents. Recent studies demonstrated that mTOR complex 1 (mTORC1) inhibitors suppress de novo biosynthesis of pyrimidine and purine nucleotides. We have previously… read more here.
Keywords: purine; rheb; interplay purinosome; purine biosynthetic ... See more keywords
Pathogenic RHEB Somatic Variant in a Child With Tuberous Sclerosis Complex Without Pathogenic Variants in TSC1 or TSC2.
Sign Up to like & getrecommendations! Published in 2023 at "Neurology"
DOI: 10.1212/wnl.0000000000207177
Abstract: OBJECTIVE To describe a child meeting diagnostic criteria for tuberous sclerosis complex (TSC) carrying a pathogenic somatic variant in RHEB, but no pathogenic variants in the two known TSC genes, TSC1 or TSC2. METHODS We… read more here.
Keywords: tsc1 tsc2; pathogenic variants; sclerosis complex; variant ... See more keywords
Rheb Promotes Triglyceride Secretion and Ameliorates Diet-Induced Steatosis in the Liver
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.808140
Abstract: Hepatosteatosis, characterized by excessive accumulation of lipids in the liver, is a major health issue in modern society. Understanding how altered hepatic lipid metabolism/homeostasis causes hepatosteatosis helps to develop therapeutic interventions. Previous studies identify mitochondrial… read more here.
Keywords: steatosis liver; triglyceride secretion; hepatosteatosis; secretion ... See more keywords
Therapeutic Potential of AAV1-Rheb(S16H) Transduction against Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22063064
Abstract: Neurotrophic factors (NTFs) are essential for cell growth, survival, synaptic plasticity, and maintenance of specific neuronal population in the central nervous system. Multiple studies have demonstrated that alterations in the levels and activities of NTFs… read more here.
Keywords: rheb s16h; neurodegenerative diseases; rheb; aav1 rheb ... See more keywords