Anti‐inflammatory effect of Rhein on ulcerative colitis via inhibiting PI3K/Akt/mTOR signaling pathway and regulating gut microbiota
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7429
Abstract: This study aimed to analyze the therapeutic effect of Rhein on ulcerative colitis (UC) in mice and its possible mechanism. LPS‐induced UC cell model and DSS‐induced UC mouse model were used to analyze the antiinflammatory… read more here.
Keywords: pi3k akt; mtor signaling; akt mtor; effect rhein ... See more keywords
Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1644-7
Abstract: Renal anti-aging protein Klotho exhibits impressive properties of anti-inflammation and renal protection, however is suppressed early after renal injury, making Klotho restoration an attractive strategy of treating renal inflammatory disorders. Here, we reported that Klotho… read more here.
Keywords: klotho preservation; tlr4; rhein; injury ... See more keywords
The influence of rhein on the absorption of rehmaionoside D: In vivo, in situ, in vitro, and in silico studies.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114650
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE In traditional Chinese Medicine, Rehmannia glutinosa (Gaertn.) DC., as the principle herb of ShengDiHuang Decotion, has the effect of cooling blood and hemostasis, and tonifying the yin and kidney. Rheum L., as adjuvant… read more here.
Keywords: absorption; resistance; glutinosa gaertn; rhein ... See more keywords
Biological evaluation and molecular docking of Rhein as a multi-targeted radiotherapy sensitization agent of nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.06.123
Abstract: Abstract Radiation resistance of nasopharyngeal carcinoma (NPC) is a joint effect caused by complex molecular mechanisms. The development of multi-target radiotherapy sensitization agents offered a promising method for the treatment of NPC. In this work,… read more here.
Keywords: radiotherapy sensitization; multi; rhein; nasopharyngeal carcinoma ... See more keywords
Comparative pharmacodynamic, pharmacokinetic and tissue distribution of Dahuang-Gancao decoction in normal and experimental constipation mice.
Sign Up to like & getrecommendations! Published in 2019 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(19)30104-9
Abstract: Dahuang-Gancao decoction (DGD) is a classical formula, which is commonly used for reliving constipation in Chinese clinic. The aim of this study was to investigate the pharmacodynamic, pharmacokinetic and tissue distribution alternations of DGD in… read more here.
Keywords: constipation mice; tissue distribution; glycyrrhizic acid; constipation ... See more keywords
Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43790
Abstract: Rhubarb and its bioactive component rhein are frequently used for the treatment of chronic kidney diseases (CKD) in eastern Asia countries. However, the potential therapeutic mechanism remains unclear. Autophagy plays an important role in CKD.… read more here.
Keywords: mtor signaling; tubular cells; rat renal; renal fibrosis ... See more keywords
Target identification and occupancy measurement of necrosis avid agent rhein using bioorthogonal chemistry-enabling probes
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02844a
Abstract: Necrosis is an important biomarker, which only occurs in pathological situations. Tracking of necrosis avid agents is of crucial importance toward understanding their mechanisms. Herein, we developed a modular probe strategy based on bioorthogonal copper-free… read more here.
Keywords: necrosis avid; chemistry; identification; rhein ... See more keywords
Acute and subchronic toxicity studies of rhein in immature and d-galactose-induced aged mice and its potential hepatotoxicity mechanisms.
Sign Up to like & getrecommendations! Published in 2020 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2020.1809670
Abstract: Rhein is a key ingredient in many herbal remedies and is widely used. However, herbs containing rhein are frequently associated with poisoning incidents, especially in elderly subjects. Acute and subchronic toxicity of rhein in Kunming… read more here.
Keywords: induced aged; acute subchronic; toxicity; subchronic toxicity ... See more keywords
A novel phenolic propanediamine moiety-based lung-targeting therapy for asthma
Sign Up to like & getrecommendations! Published in 2018 at "Drug Delivery"
DOI: 10.1080/10717544.2018.1472675
Abstract: Abstract Asthma is one of the most prevalent chronic inflammatory diseases of lung. Current asthma therapy using inhaled corticosteroid often results in undesired treatment outcome due to poor compliance and drugs’ lack of tissue specificity.… read more here.
Keywords: propanediamine; lung targeting; therapy; rhein ... See more keywords
The natural agent rhein induces β‐catenin degradation and tumour growth arrest
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13346
Abstract: The natural agent rhein is an ananthraquinone derivative of rhubarb, which has anticancer effects. To determine the mechanisms underlying the anticancer effects of rhein, we detected the effect of rhein on several oncoproteins. Here, we… read more here.
Keywords: catenin; rhein induces; rhein; growth ... See more keywords
Rhein induces bone regeneration via alleviating inflammation in murine periodontitis model.
Sign Up to like & getrecommendations! Published in 2023 at "Oral diseases"
DOI: 10.1111/odi.14502
Abstract: OBJECTIVE To evaluate the effect of rhein on eliminating the inflammation and promoting bone regeneration of periodontitis after local administration. MATERIALS AND METHODS In vivo, periodontitis model was established in murine mandibular first molar by… read more here.
Keywords: inflammation; periodontitis model; periodontitis; bone regeneration ... See more keywords