Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population
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DOI: 10.1002/pro.4222
Abstract: Some protein positions play special roles in determining the magnitude of protein function: at such “rheostat” positions, varied amino acid substitutions give rise to a continuum of functional outcomes, from wild type (or enhanced), to… read more here.
Keywords: rheostat positions; human aldolase; substitutions rheostat; position human ... See more keywords
Odd one out? Functional tuning of Zymomonas mobilis pyruvate kinase is narrower than its allosteric, human counterpart
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DOI: 10.1002/pro.4336
Abstract: Various protein properties are often illuminated using sequence comparisons of protein homologs. For example, in analyses of the pyruvate kinase multiple sequence alignment, the set of positions that changed during speciation (“phylogenetic” positions) were enriched… read more here.
Keywords: zymomonas mobilis; pyruvate kinase; zmpyk; rheostat positions ... See more keywords
Rheostat positions: A new classification of protein positions relevant to pharmacogenomics
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DOI: 10.1007/s00044-020-02582-9
Abstract: To achieve the full potential of pharmacogenomics, one must accurately predict the functional outcomes that arise from amino acid substitutions in proteins. Classically, researchers have focused on understanding the consequences of individual substitutions. However, literature… read more here.
Keywords: protein; amino acid; rheostat positions; protein positions ... See more keywords