A multicenter phase II trial of primary prophylactic PEG-rhG-CSF in pediatric patients with solid tumors and non-Hodgkin lymphoma after chemotherapy: An interim analysis.
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DOI: 10.1002/cam4.6079
Abstract: BACKGROUND Pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) can be used in pediatric patients. This study assessed the safety and efficacy of PEG-rhG-CSF as a primary prophylactic drug against neutropenia after chemotherapy in pediatric patients… read more here.
Keywords: peg rhg; pediatric patients; rhg csf;
Pharmacokinetics and Pharmacodynamics of Two Formulations of Pegylated Recombinant Human Granulocyte Colony‐Stimulating Factor in Healthy Chinese Subjects: An Open‐Label, Randomized, Parallel‐Design Bioavailability Study
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DOI: 10.1002/cpdd.819
Abstract: Pegylated recombinant human granulocyte colony‐stimulating factor (PEG‐rhG‐CSF, pegfilgrastim) is a long‐acting derivative of recombinant human granulocyte colony‐stimulating factor with limited renal clearance and a longer half‐life. It is used for the prevention of febrile neutropenia,… read more here.
Keywords: recombinant human; treatment; peg rhg; rhg csf ... See more keywords
PEG-rhG-CSF versus rhG-CSF in supporting neutrophil recovery after induction chemotherapy for patients with newly diagnosed acute lymphoblastic leukemia
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DOI: 10.1007/s00277-025-06183-7
Abstract: To compare the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) and rhG-CSF in the recovery of neutrophils after induction therapy in ALL patients, PEG-rhG-CSF was injected subcutaneously within 24 ~ 48 h after… read more here.
Keywords: chemotherapy; csf; rhg csf; peg rhg ... See more keywords
Randomized controlled clinical trial of polyethylene glycol recombinant human granulocyte colony-stimulating factor in the treatment of neutropenia after chemotherapy for breast cancer
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DOI: 10.1007/s00280-018-3639-z
Abstract: PurposeTo explore the efficacy and safety of daily administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF), and a single subcutaneous injection of polyethylene glycol recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF, a sustained-duration rhG-CSF) in neutropenia… read more here.
Keywords: chemotherapy; recombinant human; csf; peg rhg ... See more keywords
Advantages with prophylactic PEG-rhG-CSF versus rhG-CSF in breast cancer patients receiving multiple cycles of myelosuppressive chemotherapy: an open-label, randomized, multicenter phase III study
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DOI: 10.1007/s10549-017-4609-6
Abstract: BackgroundPEG-rhG-CSF reduces neutropenia and improves chemotherapy safety. In China’s registration trial (CFDA: 2006L01305), we assessed its efficacy and safety against rhG-CSF, and prospectively explored its value over multiple cycles of chemotherapy.MethodsIn this open-label, randomized, multicenter… read more here.
Keywords: incidence; peg rhg; rhg csf; csf ... See more keywords
A prospective, randomized clinical trial of emergency treatment of chemotherapy‐induced neutropenia and febrile neutropenia by pegylated recombinant human granulocyte colony‐stimulating factor (PEG‐rhG‐CSF)
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15507
Abstract: As one of the mainstays of breast cancer therapy, chemotherapy inevitably induces neutropenia. In this study, we explored the role of PEG‐rhG‐CSF (pegylated recombinant human granulocyte colony‐stimulating factor) in the emergency treatment of chemotherapy‐induced grades… read more here.
Keywords: peg rhg; pegylated recombinant; human granulocyte; rhg csf ... See more keywords
Anaphylaxis caused by pegylated recombinant human granulocyte colony-stimulating factor
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DOI: 10.1177/10781552221112323
Abstract: Introduction Pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF), is commonly used to prevent and/or treat neutropenia caused by tumor chemotherapy and radiotherapy with reduced clearance, increased plasma half-life, sustained biologic activity, and good safety. PEG-rhG-CSF… read more here.
Keywords: peg rhg; anaphylaxis; rhg csf;
Clinical study on the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor injection (PEG-rhG-CSF) in autologous hematopoietic stem cell mobilization for lymphoma - Results of interim analysis
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DOI: 10.1182/blood-2025-2408
Abstract: Background: Both PEG-rhG-CSF and rhG-CSF are widely used in autologous hematopoietic stem cell mobilization for lymphoma. There is still a lack of prospective studies comparing the two mobilizing agents in autologous stem cell mobilization for… read more here.
Keywords: mobilization; rhg csf; group; peg rhg ... See more keywords
Process Development for Production and Purification of PEGylated RhG-CSF Expressed in Escherichia Coli.
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DOI: 10.2174/0929866529666220126100559
Abstract: BACKGROUND AND OBJECTIVE Recombinant human granulocyte-colony stimulating factor (rhG-CSF) and its PEGylated form (PEG-GCSF) are used in the cancer therapy. Thus the development of a more cost-effectively method for expressing rhG-CSF and the PEGylation optimization… read more here.
Keywords: purification; csf; rhg csf; peg gcsf ... See more keywords
Preparation and Characterization of Site-Specific Fatty Chain-Modified Recombinant Human Granulocyte Colony Stimulating Factor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.923059
Abstract: The clinical use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) is limited by its short serum half-life. In this study, a long-acting strategy for site-specific modification of rhG-CSF with 1-pentadecyl-1H-pyrrole-2,5-dione (C15 fatty chain-maleimide, C15-MAL) was… read more here.
Keywords: rhg; recombinant human; c15 rhg; rhg csf ... See more keywords
Pegylated recombinant human granulocyte colony-stimulating factor enhances radiotherapy completion and safety in concurrent chemoradiotherapy for cervical cancer: a retrospective analysis
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DOI: 10.3389/fonc.2025.1640418
Abstract: Objective To evaluate the impact of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) on radiotherapy completion rates and safety in cervical cancer patients undergoing concurrent chemoradiotherapy. Methods This retrospective study analyzed 60 cervical cancer patients… read more here.
Keywords: csf group; csf; rhg csf; peg rhg ... See more keywords