Blockage of undesirable endocytosis of recombinant human growth/differentiation factor‐5 in Chinese hamster ovary cell cultures requires heparin analogs with specific chain lengths
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DOI: 10.1002/biot.202100227
Abstract: Cell surface heparan sulfate proteoglycan (HSPG)‐mediated endocytosis lowers the yield of recombinant human bone morphogenetic proteins (rhBMPs), such as rhBMP‐2 and rhBMP‐4, from Chinese hamster ovary (CHO) cell cultures. Exogenous recombinant human growth/differentiation factor‐5 (rhGDF‐5),… read more here.
Keywords: chain; recombinant human; rhgdf internalization; cell cultures ... See more keywords