Intra-articular therapy with recombinant human GDF5 arrests disease progression and stimulates cartilage repair in the rat medial meniscus transection (MMT) model of osteoarthritis.
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DOI: 10.1016/j.joca.2016.11.002
Abstract: OBJECTIVE Investigation of osteoarthritis (OA) risk alleles suggests that reduced levels of growth and differentiation factor-5 (GDF5) may be a precipitating factor in OA. We hypothesized that intra-articular recombinant human GDF5 (rhGDF5) supplementation to the… read more here.
Keywords: progression; osteoarthritis; gdf5; rhgdf5 ... See more keywords