Overexpression, overproduction, purification, and characterization of rhGH in Escherichia coli
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1902
Abstract: Overexpression of insoluble human growth hormone (hGH) in cytoplasm was achieved by E. coli Rosetta‐gami B(DE3) [pET21a (+)‐hGH]). For overexpression of hGH, effects of eight factors including temperature, type and concentration of carbon source, IPTG… read more here.
Keywords: overexpression; overexpression overproduction; rhgh; rhgh production ... See more keywords
Evaluation of fibronectin 1 in one dried blood spot and in urine after rhGH treatment.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2108
Abstract: Since the appearance of recombinant human growth hormone (rhGH) in the 1980s, its expansion and acquisition through the black market has increased, so the detection of its abuse continues to be a challenge. New biomarkers… read more here.
Keywords: one dried; spot urine; rhgh; blood spot ... See more keywords
P182125 YEARS OF GROWTH HORMONE TREATMENT IN CHILDREN WITH CHRONIC KIDNEY DISEASE IN POLAND - RESULTS OF NATIONAL MULTICENTER STUDY
Sign Up to like & getrecommendations! Published in 2017 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p1821
Abstract: Growth retardation is one of considerable problems in children with chronic kidney disease (CKD) with a great impact on life activity and quality of life. Recombinant human growth hormone (rhGH) treatment has been used for… read more here.
Keywords: children ckd; rhgh; treatment; growth velocity ... See more keywords
Adult Height of Patients with SHOX Haploinsufficiency with or without GH Therapy: A Real-World Single-Center Study
Sign Up to like & getrecommendations! Published in 2022 at "Hormone Research in Paediatrics"
DOI: 10.1159/000524374
Abstract: Introduction: Isolated SHOX haploinsufficiency is a common monogenic cause of short stature. Few studies compare untreated and rhGH-treated patients up to adult height (AH). Our study highlights a growth pattern from childhood to AH in… read more here.
Keywords: rhgh; patients shox; rhgh treated; adult height ... See more keywords
Effect of Growth Hormone Therapy on Pubertal Timing: Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Hormone research in paediatrics"
DOI: 10.1159/000530578
Abstract: Introduction Recombinant human growth hormone (rhGH) therapy effectively increases height in various disorders of childhood growth. However, whether rhGH affects pubertal timing is unclear. We aimed to review systematically published evidence on the effect of… read more here.
Keywords: growth; rhgh; pubertal timing; growth hormone ... See more keywords
Approach to growth hormone therapy in children with chronic kidney disease varies across North America: the Midwest Pediatric Nephrology Consortium report
Sign Up to like & getrecommendations! Published in 2017 at "BMC Nephrology"
DOI: 10.1186/s12882-017-0599-1
Abstract: BackgroundGrowth impairment remains common in children with chronic kidney disease (CKD). Available literature indicates low level of recombinant human growth hormone (rhGH) utilization in short children with CKD. Despite efforts at consensus guidelines, lack of… read more here.
Keywords: nephrology; pediatric nephrology; rhgh; endocrinology ... See more keywords
Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation
Sign Up to like & getrecommendations! Published in 2019 at "Italian Journal of Pediatrics"
DOI: 10.1186/s13052-019-0715-x
Abstract: Recombinant human growth hormone (rhGH) is an approved and effective treatment for short children born small for gestational age (SGA). Prevalence of children eligible for treatment as SGA is reported to be 1:1800. The latest… read more here.
Keywords: born small; rhgh; small gestational; treatment ... See more keywords
Effects of recombinant human growth hormone on proliferation and differentiation of cementoblast and ERK1 / 2, JNK / SAPK and p38MAPK signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2022.68.7.8
Abstract: To investigate the effects of recombinant human growth hormone on the proliferation and differentiation of cementoblast and the signal pathways of ERK1 / 2, JNK / SAPK and p38MAPK, osteoblasts (OCCM-30) were cultured in vitro.… read more here.
Keywords: rhgh; sapk; proliferation; group ... See more keywords
Ten years’ clinical experience with biosimilar human growth hormone: a review of efficacy data
Sign Up to like & getrecommendations! Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s130320
Abstract: In 2006, the European Medicines Agency (EMA) approved Omnitrope® as a biosimilar recombinant human growth hormone (rhGH), on the basis of comparable quality, safety, and efficacy to the reference medicine (Genotropin®, Pfizer). Data continue to… read more here.
Keywords: growth hormone; rhgh; biosimilar rhgh; efficacy ... See more keywords
Ten years of clinical experience with biosimilar human growth hormone: a review of safety data
Sign Up to like & getrecommendations! Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s130909
Abstract: Safety concerns for recombinant human growth hormone (rhGH) treatments include impact on cancer risk, impact on glucose homeostasis, and the formation of antibodies to endogenous/exogenous GH. Omnitrope® (biosimilar rhGH) was approved by the European Medicines… read more here.
Keywords: medicine; rhgh; human growth; safety ... See more keywords
Phase 2 Randomized, Placebo-Controlled Clinical Trial of Recombinant Human Growth Hormone (rhGH) During Rehabilitation From Traumatic Brain Injury
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00520
Abstract: Traumatic brain injury (TBI) is a major cause of death and disability, but there are currently no therapies with proven efficacy for optimizing regeneration of repair during rehabilitation. Using standard stimulation tests, as many as… read more here.
Keywords: rehabilitation; growth hormone; recombinant human; rhgh ... See more keywords