Practically feasible production of sustained‐release microspheres of granulocyte‐macrophage colony‐stimulating factor (rhGM‐CSF)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.04.004
Abstract: ABSTRACT Using recombinant human granulocyte‐macrophage colony‐stimulating factor (rhGM‐CSF) as a model drug, the present study demonstrated a practically feasible process to produce polymeric microspheres for sustained‐release delivery of protein drugs with preserved integrity. This process… read more here.
Keywords: release; macrophage colony; practically feasible; rhgm csf ... See more keywords
Autoimmune pulmonary alveolar proteinosis in an adolescent successfully treated with inhaled rhGM-CSF (molgramostim)
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DOI: 10.1016/j.rmcr.2018.02.005
Abstract: Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare parenchymal lung disease characterized by accumulation of surfactant in the airways with high levels of granulocyte-macrophage colony stimulating factor (GM-CSF) antibodies in blood. Disease leads to hypoxemic… read more here.
Keywords: pulmonary alveolar; csf; alveolar proteinosis; successfully treated ... See more keywords
Clinical study of rhGM-CSF for the treatment of pulmonary exogenous acute respiratory distress syndrome by modulating alveolar macrophage subtypes: A randomized controlled trial
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DOI: 10.1097/md.0000000000033770
Abstract: Background: By modulating the oxygen partial pressure of alveolar epithelial cells, the granulocyte-macrophage colony-stimulating factor (GM-CSF) can stimulate and enhance the innate immune response in the lungs. This study aimed to investigate the therapeutic efficacy… read more here.
Keywords: respiratory distress; group; rhgm csf; acute respiratory ... See more keywords
Pichia pastoris versus Saccharomyces cerevisiae: a case study on the recombinant production of human granulocyte-macrophage colony-stimulating factor
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DOI: 10.1186/s13104-017-2471-6
Abstract: BackgroundRecombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) is a glycoprotein that has been approved by the FDA for the treatment of neutropenia and leukemia in combination with chemotherapies. Recombinant hGM-CSF is produced industrially using the baker’s… read more here.
Keywords: pastoris; csf; macrophage colony; human granulocyte ... See more keywords