Herpes simplex virus encoded ICP6 protein forms functional amyloid assemblies with necroptosis-associated host proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2020.106524
Abstract: The viral protein ICP6, encoded by herpes simplex virus 1 (HSV-1), harbours a RIP-homotypic interaction motif (RHIM), that plays a role in viral inhibition of host cell death pathways. Other members of the Herpesviridae family… read more here.
Keywords: protein; amyloid assemblies; rhim; host ... See more keywords
TAT–RHIM: a more complex issue than expected
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DOI: 10.1042/bcj20210677
Abstract: Murine cytomegalovirus protein M45 contains a RIP homotypic interaction motif (RHIM) that is sufficient to confer protection of infected cells against necroptotic cell death. Mechanistically, the N-terminal region of M45 drives rapid self-assembly into homo-oligomeric… read more here.
Keywords: cell death; cell; domain; rhim ... See more keywords
Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death
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DOI: 10.1371/journal.ppat.1008473
Abstract: Herpesviruses are known to encode a number of inhibitors of host cell death, including RIP Homotypic Interaction Motif (RHIM)-containing proteins. Varicella zoster virus (VZV) is a member of the alphaherpesvirus subfamily and is responsible for… read more here.
Keywords: zoster virus; rhim; orf20 rhim; cell death ... See more keywords