Elucidation of the hetero-dimeric binding activity of LasR and RhlR proteins with the promoter DNA and the role of a specific Phe residue during the biosynthesis of HCN synthase from opportunistic pathogen Pseudomonas aeruginosa
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DOI: 10.1007/s00894-021-04701-8
Abstract: Pseudomonas aeruginosa is an opportunistic human pathogen. It causes secondary infections in patients suffering from cancer and other immunological disorders. The pathogenicity of the organism is dependent on the ability of the organism to code… read more here.
Keywords: rhlr; hcn synthase; pseudomonas aeruginosa; promoter dna ... See more keywords
RhlR-Regulated Acyl-Homoserine Lactone Quorum Sensing in a Cystic Fibrosis Isolate of Pseudomonas aeruginosa
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DOI: 10.1128/mbio.00532-20
Abstract: Pseudomonas aeruginosa is a prominent cystic fibrosis (CF) pathogen that uses quorum sensing (QS) to regulate virulence. In laboratory strains, the key QS regulator is LasR. Many isolates from patients with chronic CF infections appear… read more here.
Keywords: isolate; quorum sensing; cystic fibrosis; rhlr ... See more keywords
Protein Interaction Networks of Catalytically Active and Catalytically Inactive PqsE in Pseudomonas aeruginosa
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DOI: 10.1128/mbio.01559-22
Abstract: Pseudomonas aeruginosa causes hospital-borne infections in vulnerable patients, including immunocompromised individuals, burn victims, and cancer patients undergoing chemotherapy. There are no effective treatments for P. aeruginosa infections, which are usually broadly resistant to antibiotics. ABSTRACT… read more here.
Keywords: interaction; rhlr; pseudomonas aeruginosa; quorum sensing ... See more keywords
The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in Pseudomonas aeruginosa
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DOI: 10.1128/spectrum.02108-21
Abstract: Bacteria use a cell-cell communication process called quorum sensing (QS) to orchestrate collective behaviors. QS relies on the group-wide detection of molecules called autoinducers (AI). ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen that causes disease… read more here.
Keywords: virulence; pqse rhlr; interaction; cell ... See more keywords
Recent Advance in Small Molecules Targeting RhlR of Pseudomonas aeruginosa
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DOI: 10.3390/antibiotics11020274
Abstract: Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic gram-negative pathogen that can cause various infections, particularly in patients with compromised host defenses. P. aeruginosa forms biofilms and produces virulence factors through quorum sensing (QS) network, resulting… read more here.
Keywords: rhlr; pseudomonas aeruginosa; advance small; molecules targeting ... See more keywords