Statistical profiling reveals correlations between the cell response to and the primary structure of Rho‐GAPs
Sign Up to like & getrecommendations! Published in 2021 at "Cytoskeleton"
DOI: 10.1002/cm.21659
Abstract: Rho‐GTPase‐activating proteins (Rho‐GAPs) are essential upstream regulators of the Rho family of GTPases. Currently, it remains unclear if the phenotypic change caused by perturbations to a Rho‐GAP is predictable from its amino acid sequence. Here… read more here.
Keywords: statistical profiling; response; primary structure; rho ... See more keywords
Characterizing variants of unknown significance in rhodopsin: A functional genomics approach
Sign Up to like & getrecommendations! Published in 2019 at "Human Mutation"
DOI: 10.1002/humu.23762
Abstract: Characterizing the pathogenicity of DNA sequence variants of unknown significance (VUS) is a major bottleneck in human genetics, and is increasingly important in determining which patients with inherited retinal diseases could benefit from gene therapy.… read more here.
Keywords: unknown significance; variants unknown; characterizing variants; rhodopsin ... See more keywords
Shen’ge powder decreases the cardiomyocyte hypertrophy in chronic heart failure by activating the Rho protein/Rho‐associated coiledcoil forming protein kinase signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27386
Abstract: The current study aimed to explore the role and the molecular mechanism of Shen’ge powder in cardiomyocyte hypertrophy in chronic heart failure (CHF). read more here.
Keywords: cardiomyocyte hypertrophy; heart failure; rho; chronic heart ... See more keywords
Flavonoids improve the stability and function of P23H rhodopsin slowing down the progression of retinitis pigmentosa in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25021
Abstract: The balanced homeostasis of the G protein–coupled receptor (GPCR), rhodopsin (Rho), is required for vision. Misfolding mutations in Rho cause photoreceptor death, leading to retinitis pigmentosa (RP) and consequently blindness. With no cure currently available,… read more here.
Keywords: retinitis pigmentosa; function; p23h rho; stability ... See more keywords
Rho-ROCK Signaling in Normal Physiology and as a Key Player in Shaping the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-35582-1_6
Abstract: The Rho-ROCK signaling network has a range of specialized functions of key biological importance, including control of essential developmental processes such as morphogenesis and physiological processes including homeostasis, immunity, and wound healing. Deregulation of Rho-ROCK… read more here.
Keywords: physiology; rho; rho rock; rock signaling ... See more keywords
Genomic prediction with multiple biparental families
Sign Up to like & getrecommendations! Published in 2019 at "Theoretical and Applied Genetics"
DOI: 10.1007/s00122-019-03445-7
Abstract: Key message For genomic prediction within biparental families using multiple biparental families, combined training sets comprising full-sibs from the same family and half-sib families are recommended to reach high and robust prediction accuracy, whereas inclusion… read more here.
Keywords: genomic prediction; multiple biparental; unrelated families; biparental families ... See more keywords
On Traffic Flow with Nonlocal Flux: A Relaxation Representation
Sign Up to like & getrecommendations! Published in 2019 at "Archive for Rational Mechanics and Analysis"
DOI: 10.1007/s00205-020-01529-z
Abstract: We consider a conservation law model of traffic flow, where the velocity of each car depends on a weighted average of the traffic density $$\rho $$ ρ ahead. The averaging kernel is of exponential type:… read more here.
Keywords: rho; relaxation; varepsilon; traffic ... See more keywords
Arithmetic representations of fundamental groups I
Sign Up to like & getrecommendations! Published in 2017 at "Inventiones mathematicae"
DOI: 10.1007/s00222-018-0810-4
Abstract: Let X be a normal algebraic variety over a finitely generated field k of characteristic zero, and let $$\ell $$ℓ be a prime. Say that a continuous $$\ell $$ℓ-adic representation $$\rho $$ρ of $$\pi _1^{\acute{\mathrm{e}}\text… read more here.
Keywords: mathrm text; ell; acute mathrm; rho ... See more keywords
Tuning the sequence specificity of a transcription terminator
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DOI: 10.1007/s00294-019-00939-1
Abstract: The bacterial hexameric helicase known as Rho is an archetypal sequence-specific transcription terminator that typically halts the synthesis of a defined set of transcripts, particularly those bearing cytosine-rich 3′-untranslated regions. However, under conditions of translational… read more here.
Keywords: tuning sequence; transcription; rho; transcription terminator ... See more keywords
Scalar conservation laws with white noise initial data
Sign Up to like & getrecommendations! Published in 2021 at "Probability Theory and Related Fields"
DOI: 10.1007/s00440-021-01083-z
Abstract: The statistical description of the scalar conservation law of the form $\rho_t=H(\rho)_x$ with $H: \mathbb{R} \rightarrow \mathbb{R}$ a smooth convex function has been an object of interest when the initial profile $\rho(\cdot,0)$ is random. The… read more here.
Keywords: conservation laws; laws white; scalar conservation; white noise ... See more keywords
A Note on Quantum Coherence
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Theoretical Physics"
DOI: 10.1007/s10773-017-3611-4
Abstract: AbstractIn this paper, we discuss the coherence of the reduced state in system HA ⊗HB under taking different quantum operations acting on subsystem HB. Firstly, we show that for a pure bipartite state, the coherence… read more here.
Keywords: state; sum; quantum; coherence ... See more keywords