Rho-Associated Kinase Inhibitor Eye Drops in challenging cataract surgery
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Ophthalmology Case Reports"
DOI: 10.1016/j.ajoc.2021.101245
Abstract: Purpose To report the impact of Rho-Associated Kinase Inhibitor Eye Drops in cases of cataract surgery performed in severe Fuchs’ endothelial corneal dystrophy (FECD). Observations A patient affected by FECD stage II underwent femtosecond laser-assisted… read more here.
Keywords: inhibitor eye; rho associated; kinase inhibitor; associated kinase ... See more keywords
Inhibition of Rho-associated kinases suppresses cardiac myofibroblast function in engineered connective and heart muscle tissues.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.06.015
Abstract: Cardiac fibrosis is a hallmark of heart failure for which there is no effective pharmacological therapy. By genetic modification and in vivo inhibitor approaches it was suggested that the Rho-associated kinases (ROCK1 and ROCK2) are… read more here.
Keywords: heart; engineered connective; inhibition; rho associated ... See more keywords
Terpinen-4-ol inhibits the proliferation and mobility of pancreatic cancer cells by downregulating Rho-associated coiled-coil containing protein kinase 2
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2054205
Abstract: ABSTRACT Terpinen-4-ol (T4O), a compound isolated from the seeds of turmeric, has exhibited anti-malignancy, anti-aging, and anti-inflammatory properties in previous studies. However, the specific effects and molecular mechanisms of T4O on pancreatic cancer (PC) cells… read more here.
Keywords: rho associated; proliferation; pancreatic cancer; coiled coil ... See more keywords
MicroRNA-23a reduces lipopolysaccharide-induced cellular apoptosis and inflammatory cytokine production through Rho-associated kinase 1/sirtuin-1/nuclear factor-kappa B crosstalk
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000001369
Abstract: Abstract Background: MicroRNAs are closely associated with the progression and outcomes of multiple human diseases, including sepsis. In this study, we examined the role of miR-23a in septic injury. Methods: Lipopolysaccharide (LPS) was used to… read more here.
Keywords: mir 23a; apoptosis; factor; rho associated ... See more keywords
Effect of Rho-associated kinase inhibitor on human corneal endothelial cell apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cataract and Refractive Surgery"
DOI: 10.1097/j.jcrs.0000000000000115
Abstract: PURPOSE To evaluate whether exposure to Rho-associated protein kinase (ROCK) inhibitor will promote human-cultured corneal endothelial cells (CECs) survival in a commercial storage medium. SETTING Edith Wolfson Medical Center, Holon, and Sheba Medical Center, Tel… read more here.
Keywords: corneal endothelial; apoptosis; rho associated; rock inhibitor ... See more keywords
Rho‐associated, coiled‐coil‐containing protein kinase 1 as a new player in the regulation of hepatic lipogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13051
Abstract: Rho‐associated, coiled‐coil‐containing protein kinase 1 might have applications as a potential therapeutic target for the treatment of non‐alcoholic fatty liver disease. read more here.
Keywords: rho associated; associated coiled; protein kinase; coiled coil ... See more keywords
Crosstalk between Substrates and Rho-Associated Kinase Inhibitors in Cryopreservation of Tissue-Engineered Constructs
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells International"
DOI: 10.1155/2017/1380304
Abstract: It is documented that human mesenchymal stem cells (hMSCs) can be differentiated into various types of cells to present a tool for tissue engineering and regenerative medicine. Thus, the preservation of stem cells is a… read more here.
Keywords: medicine; associated kinase; rho associated; tissue ... See more keywords
The Rho-associated kinase inhibitor fasudil can replace Y-27632 for use in human pluripotent stem cell research
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0233057
Abstract: Poor survival of human pluripotent stem cells (hPSCs) following freezing, thawing, or passaging hinders the maintenance and differentiation of stem cells. Rho-associated kinases (ROCKs) play a crucial role in hPSC survival. To date, a typical… read more here.
Keywords: research; inhibitor; human pluripotent; rho associated ... See more keywords
Involvement of Rho-associated coiled-coil kinase signaling inhibition in TGF-β1/Smad2, 3 signal transduction in vitro.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2017.12.03
Abstract: AIM To research the effect of Y-27632, a selective Rho-associated coiled-coil kinase (ROCK) inhibitor, on TGF-β1/Smad2, 3 signal transduction in ocular Tenon's capsule fibroblasts (OTFs). METHODS Primary ocular Tenon's capsule fibroblasts had been cultured in… read more here.
Keywords: tgf smad2; coil kinase; rho associated; tgf ... See more keywords
Inflammation and Rho-Associated Protein Kinase-Induced Brain Changes in Vascular Dementia
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020446
Abstract: Patients with vascular dementia, caused by cerebral ischemia, experience long-term cognitive impairment due to the lack of effective treatment. The mechanisms of and treatments for vascular dementia have been investigated in various animal models; however,… read more here.
Keywords: associated protein; protein kinase; rho associated; vascular dementia ... See more keywords