Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13802
Abstract: The Ras homology (Rho) family of GTPases serves various functions, including promotion of cell migration, adhesion, and transcription, through activation of effector molecule targets. One such pair of effectors, the Rho‐associated coiled‐coil kinases (ROCK1 and… read more here.
Keywords: rock1 rock2; mice; cell; adult mice ... See more keywords
Rho-Associated Kinase Inhibitor Eye Drops in challenging cataract surgery
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Ophthalmology Case Reports"
DOI: 10.1016/j.ajoc.2021.101245
Abstract: Purpose To report the impact of Rho-Associated Kinase Inhibitor Eye Drops in cases of cataract surgery performed in severe Fuchs’ endothelial corneal dystrophy (FECD). Observations A patient affected by FECD stage II underwent femtosecond laser-assisted… read more here.
Keywords: inhibitor eye; rho associated; kinase inhibitor; associated kinase ... See more keywords
Inhibition of Rho-associated kinases suppresses cardiac myofibroblast function in engineered connective and heart muscle tissues.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.06.015
Abstract: Cardiac fibrosis is a hallmark of heart failure for which there is no effective pharmacological therapy. By genetic modification and in vivo inhibitor approaches it was suggested that the Rho-associated kinases (ROCK1 and ROCK2) are… read more here.
Keywords: heart; engineered connective; inhibition; rho associated ... See more keywords
Terpinen-4-ol inhibits the proliferation and mobility of pancreatic cancer cells by downregulating Rho-associated coiled-coil containing protein kinase 2
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2054205
Abstract: ABSTRACT Terpinen-4-ol (T4O), a compound isolated from the seeds of turmeric, has exhibited anti-malignancy, anti-aging, and anti-inflammatory properties in previous studies. However, the specific effects and molecular mechanisms of T4O on pancreatic cancer (PC) cells… read more here.
Keywords: rho associated; proliferation; pancreatic cancer; coiled coil ... See more keywords
Ethanolic Extract of Atractylodis Rhizoma Ameliorates DSS-Induced Ulcerative Colitis via Improving Intestinal Barrier Function Through the Rho-Associated Kinase/Myosin Light Chain Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medicinal Food"
DOI: 10.1089/jmf.2024.k.0281
Abstract: The utilization of traditional Chinese medicine (TCM) for disease treatment dates back thousands of years. Atractylodis rhizoma (AR) is recognized as a premier TCM and has effective therapeutic properties for gastrointestinal disorders. Nonetheless, the underlying… read more here.
Keywords: ethanolic extract; dss induced; ulcerative colitis; atractylodis rhizoma ... See more keywords
MicroRNA-23a reduces lipopolysaccharide-induced cellular apoptosis and inflammatory cytokine production through Rho-associated kinase 1/sirtuin-1/nuclear factor-kappa B crosstalk
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000001369
Abstract: Abstract Background: MicroRNAs are closely associated with the progression and outcomes of multiple human diseases, including sepsis. In this study, we examined the role of miR-23a in septic injury. Methods: Lipopolysaccharide (LPS) was used to… read more here.
Keywords: mir 23a; apoptosis; factor; rho associated ... See more keywords
Effect of Rho-associated kinase inhibitor on human corneal endothelial cell apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cataract and Refractive Surgery"
DOI: 10.1097/j.jcrs.0000000000000115
Abstract: PURPOSE To evaluate whether exposure to Rho-associated protein kinase (ROCK) inhibitor will promote human-cultured corneal endothelial cells (CECs) survival in a commercial storage medium. SETTING Edith Wolfson Medical Center, Holon, and Sheba Medical Center, Tel… read more here.
Keywords: corneal endothelial; apoptosis; rho associated; rock inhibitor ... See more keywords
Rho‐associated, coiled‐coil‐containing protein kinase 1 as a new player in the regulation of hepatic lipogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13051
Abstract: Rho‐associated, coiled‐coil‐containing protein kinase 1 might have applications as a potential therapeutic target for the treatment of non‐alcoholic fatty liver disease. read more here.
Keywords: rho associated; associated coiled; protein kinase; coiled coil ... See more keywords
Crosstalk between Substrates and Rho-Associated Kinase Inhibitors in Cryopreservation of Tissue-Engineered Constructs
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells International"
DOI: 10.1155/2017/1380304
Abstract: It is documented that human mesenchymal stem cells (hMSCs) can be differentiated into various types of cells to present a tool for tissue engineering and regenerative medicine. Thus, the preservation of stem cells is a… read more here.
Keywords: medicine; associated kinase; rho associated; tissue ... See more keywords
The Rho-associated kinase inhibitor fasudil can replace Y-27632 for use in human pluripotent stem cell research
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0233057
Abstract: Poor survival of human pluripotent stem cells (hPSCs) following freezing, thawing, or passaging hinders the maintenance and differentiation of stem cells. Rho-associated kinases (ROCKs) play a crucial role in hPSC survival. To date, a typical… read more here.
Keywords: research; inhibitor; human pluripotent; rho associated ... See more keywords
Involvement of Rho-associated coiled-coil kinase signaling inhibition in TGF-β1/Smad2, 3 signal transduction in vitro.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2017.12.03
Abstract: AIM To research the effect of Y-27632, a selective Rho-associated coiled-coil kinase (ROCK) inhibitor, on TGF-β1/Smad2, 3 signal transduction in ocular Tenon's capsule fibroblasts (OTFs). METHODS Primary ocular Tenon's capsule fibroblasts had been cultured in… read more here.
Keywords: tgf smad2; coil kinase; rho associated; tgf ... See more keywords