Corrigendum: A GAL4‐inducible transgenic tool kit for the in vivo modulation of Rho GTPase activity in zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24509
Abstract: Fig. 1. Overview of transgenic constructs. A: Myc-tagged Cdc42 and RhoA constructs are placed downstream of mCherry and the self-cleaving viral peptide f2a, enabling their bicistronic expression following activation of the 10xuas promoter. 10xuas activation… read more here.
Keywords: corrigendum gal4; rho gtpase; inducible transgenic; gal4 inducible ... See more keywords
N‐myc downstream‐regulated gene 2 controls astrocyte morphology via Rho‐GTPase signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28689
Abstract: Astrocyte undergoes morphology changes that are closely associated with the signaling communications at synapses. N‐myc downstream‐regulated gene 2 (NDRG2) is specifically expressed in astrocytes and is associated with several important astrocyte functions, but its potential… read more here.
Keywords: protein expression; rho gtpase; expression; gtpase signaling ... See more keywords
DBS is activated by EPHB2/SRC signaling-mediated tyrosine phosphorylation in HEK293 cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03552-5
Abstract: It is well known that Rho family small GTPases (Rho GTPase) has a role of molecular switch in intracellular signal transduction. The switch cycle between GTP-bound and GDP-bound state of Rho GTPase regulates various cell… read more here.
Keywords: rho gtpase; dbs; ephb2 src; src ... See more keywords
Exploration of potential role of Rho GTPase in nicotine dependence-induced withdrawal syndrome in mice
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-021-17059-4
Abstract: The RhoA gene showed an important genotypic association with nicotine dependence and smoking initiation. The current study aims to investigate the effect of the Rho GTPase inhibitor ML141 in the progression of nicotine dependence in… read more here.
Keywords: rho gtpase; nicotine dependence; gtpase; withdrawal syndrome ... See more keywords
Rho GTPase regulatory proteins in podocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.08.035
Abstract: Rho-family of small GTPases (Rho GTPases) are the master regulators of the actin cytoskeleton and consist of 22 members. Previous studies implicated dysregulation of Rho GTPases in podocytes in the pathogenesis of proteinuric glomerular diseases.… read more here.
Keywords: regulatory proteins; rho gtpase; proteins podocytes; gtpase regulatory ... See more keywords
Plant Rho GTPase signaling promotes autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular plant"
DOI: 10.1016/j.molp.2021.03.021
Abstract: The roles of rho-family guanosine triphosphatases (GTPases) of plants (ROPs) in modulating plant growth and development have been well-characterized. However, little is known about the roles of ROP signaling pathways in regulating plant autophagy and… read more here.
Keywords: plant; rop8; rho gtpase; plant rho ... See more keywords
Proto-oncogene serine/threonine kinase PIM3 promotes cell migration via modulating Rho GTPase signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00821
Abstract: The proto-oncogene serine/threonine-protein kinase PIM3 plays critical roles in cancer, and it has been extensively exploited as a drug target. Here we investigated the quantitative changes in the cellular proteome and phosphoproteome in liver cancer… read more here.
Keywords: pim3; cell migration; proto oncogene; rho gtpase ... See more keywords
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00408
Abstract: Toxins TcdA and TcdB from Clostridioides difficile glucosylate human colon Rho GTPases. TcdA and TcdB glucosylation of RhoGTPases results in cytoskeletal changes, causing cell rounding and loss of intestinal integrity. Clostridial toxins TcdA and TcdB… read more here.
Keywords: transition state; rho gtpase; sni mechanism; stereochemistry ... See more keywords
The Rho GTPase signalling pathway in urothelial carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Urology"
DOI: 10.1038/nrurol.2017.184
Abstract: Urothelial carcinoma remains a clinical challenge: non-muscle-invasive disease has a high rate of recurrence and risk of progression, and outcomes for patients with advanced disease are poor, owing to a lack of effective systemic therapies.… read more here.
Keywords: carcinoma; rho gtpase; gtpase signalling; signalling pathway ... See more keywords
Rho GTPase gene expression and breast cancer risk: a Mendelian randomization analysis
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05549-5
Abstract: The Rho GTPase family consists of 20 genes encoding intracellular signalling proteins that influence cytoskeletal dynamics, cell migration and cell cycle progression. They are implicated in breast cancer progression but their role in breast cancer… read more here.
Keywords: breast; breast cancer; expression; rho gtpase ... See more keywords
Effects of the Rho GTPase‐activating toxin CNF1 on fibroblasts derived from Rett syndrome patients: A pilot study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17624
Abstract: The bacterial product CNF1, through its action on the Rho GTPases, is emerging as a modulator of crucial signalling pathways involved in selected neurological diseases characterized by mitochondrial dysfunctions. Mitochondrial impairment has been hypothesized to… read more here.
Keywords: rho gtpase; gtpase activating; rett syndrome; rtt fibroblasts ... See more keywords