Effect of cadmium on Rho GTPases signal transduction during osteoclast differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23510
Abstract: Osteoclasts are the key target cells for cadmium (Cd)‐induced bone metabolism diseases, while Rho GTPases play an important role in osteoclast differentiation and bone resorption. To identify new therapeutic targets of Cd‐induced bone diseases; we… read more here.
Keywords: osteoclast differentiation; cadmium; signal transduction; rho gtpases ... See more keywords
Control of adhesion and protrusion in cell migration by Rho GTPases
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Cell Biology"
DOI: 10.1016/j.ceb.2018.09.003
Abstract: Cell migration is a critical process that underpins a number of physiological and pathological contexts such as the correct functioning of the immune system and the spread of metastatic cancer cells. Central to this process… read more here.
Keywords: cell migration; cell; rho gtpases; migration rho ... See more keywords
Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107721
Abstract: SUMMARY Burkholderia cenocepacia is an opportunistic bacterial pathogen that causes severe pulmonary infections in cystic fibrosis and chronic granulomatous disease patients. B. cenocepacia can survive inside infected macrophages within the B. cenocepacia-containing vacuole (BcCV) and… read more here.
Keywords: inactivation rho; rho gtpases; cenocepacia induces; burkholderia cenocepacia ... See more keywords
Rho GTPase regulatory proteins in podocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.08.035
Abstract: Rho-family of small GTPases (Rho GTPases) are the master regulators of the actin cytoskeleton and consist of 22 members. Previous studies implicated dysregulation of Rho GTPases in podocytes in the pathogenesis of proteinuric glomerular diseases.… read more here.
Keywords: regulatory proteins; rho gtpase; proteins podocytes; gtpase regulatory ... See more keywords
Role of Membrane Tension Sensitive Endocytosis and Rho GTPases in the Uptake of the Alzheimer’s Disease Peptide Aβ(1-42)
Sign Up to like & getrecommendations! Published in 2020 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.0c00053
Abstract: Intraneuronal accumulation of amyloid-β (Aβ) is an early pathological signum of Alzheimer’s disease, and compartments of the endolysosomal system have been implicated in both seeding and cell–cell propagation of Aβ aggregation. We have studied how… read more here.
Keywords: alzheimer disease; membrane tension; cell; rho gtpases ... See more keywords
Rho GTPases: Anti- or Pro-neoplastic Targets?
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.473
Abstract: Rho GTPases are critical signal transducers of multiple pathways. They have been proposed to be useful anti-neoplastic targets for over two decades, especially in Ras-driven cancers. Until recently, however, few in vivo studies had been… read more here.
Keywords: neoplastic targets; cancer; pro neoplastic; gtpases anti ... See more keywords
The role of Rho GTPases’ substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20200407
Abstract: Abstract Recently, Rho GTPases substrates include Rac (Rac1 and Rac2) and Cdc42 that have been reported to exert multiple cellular functions in osteoclasts, the most prominent of which includes regulating the dynamic actin cytoskeleton rearrangements.… read more here.
Keywords: cdc42; role rho; role; rho gtpases ... See more keywords
Flavonoids extracted from leaves of Diospyros kaki regulates RhoA activity to rescue synapse loss and reverse memory impairment in APP/PS1 mice
Sign Up to like & getrecommendations! Published in 2018 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000989
Abstract: Synapse dysfunction is an early hallmark of Alzheimer’s disease (AD), and was considered to be closely related to memory loss. The molecular mechanisms that trigger synapse loss and dysfunction remain poorly understood. Increasing evidence shows… read more here.
Keywords: synapse loss; rho gtpases; ps1 mice; app ps1 ... See more keywords
Transcriptomic Analysis Reveals That Rho GTPases Regulate Trap Development and Lifestyle Transition of the Nematode-Trapping Fungus Arthrobotrys oligospora
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01759-21
Abstract: Nematode-trapping (NT) fungi are widely distributed in terrestrial and aquatic ecosystems. Their broad adaptability and flexible lifestyles make them ideal agents for controlling pathogenic nematodes. Arthrobotrys oligospora is a model species employed for understanding the… read more here.
Keywords: arthrobotrys oligospora; trap; analysis; rho gtpases ... See more keywords
Regulation of Rho GTPases in the Vasculature by Cullin3-Based E3 Ligase Complexes
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.680901
Abstract: Cullin3-based ubiquitin E3 ligases induce ubiquitination of substrates leading to their proteasomal or lysosomal degradation. BTB proteins serve as adaptors by binding to Cullin3 and recruiting substrate proteins, which enables specific recognition of a broad… read more here.
Keywords: ligase complexes; regulation rho; cullin3; cullin3 based ... See more keywords
Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.820945
Abstract: Platelet cytoskeletal reorganisation is a critical component of platelet activation and thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the primary drivers in the dynamic reorganisation process, leading to the development… read more here.
Keywords: platelet; activity; turning platelets; platelets role ... See more keywords