Statins ameliorate pulmonary hypertension secondary to left ventricular dysfunction through the Rho‐kinase pathway and NADPH oxidase
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.23610
Abstract: Pulmonary hypertension (PH) is a devastating disorder, for which no therapy is curative. It has been reported that pulmonary vascular remodeling, associated with increasing mean pulmonary arterial pressure and upregulated expression of endothelial nitric oxide… read more here.
Keywords: pulmonary hypertension; kinase pathway; secondary left; ventricular dysfunction ... See more keywords
Rho‐kinase inhibitors protect against neonatal hyperoxia‐induced airway hyperreactivity in a rat pup model: Role of prostaglandin F2α
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.25848
Abstract: Oxygen therapy in preterm neonates is associated with airway hyperreactivity. The role of Rho/Rho‐kinase smooth muscle signaling in hyperoxia‐induced airway hyperreactivity remains understudied. We hypothesized that inhibition of Rho‐kinase will attenuate airway hyperreactivity induced by… read more here.
Keywords: hyperoxia induced; rho kinase; induced airway; airway hyperreactivity ... See more keywords
RKI-1447, a Rho kinase inhibitor, causes ocular hypotension, actin stress fiber disruption, and increased phagocytosis
Sign Up to like & getrecommendations! Published in 2018 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-018-4175-6
Abstract: PurposeThis study investigated the hypotensive effect of RKI-1447, a Rho kinase inhibitor, in a porcine ex vivo pigmentary glaucoma model.MethodsTwenty-eight porcine anterior chambers were perfused with medium supplemented with 1.67 × 107 pigment particles/ml for 48 h before… read more here.
Keywords: phagocytosis; rki 1447; pigment; rho kinase ... See more keywords
Rho kinase inhibitors—a review on the physiology and clinical use in Ophthalmology
Sign Up to like & getrecommendations! Published in 2019 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-019-04283-5
Abstract: The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway in the human eye has been hypothesized to play… read more here.
Keywords: physiology; rho kinase; ophthalmology; rock signaling ... See more keywords
Two Phase 3 Clinical Trials Comparing the Safety and Efficacy of Netarsudil to Timolol in Patients With Elevated Intraocular Pressure: Rho Kinase Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 and ROCKET-2).
Sign Up to like & getrecommendations! Published in 2018 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2017.11.019
Abstract: PURPOSE To evaluate the efficacy and ocular and systemic safety of netarsudil 0.02% ophthalmic solution, a rho-kinase inhibitor and norepinephrine transporter inhibitor, in patients with open-angle glaucoma and ocular hypertension. DESIGN Double-masked, randomized noninferiority clinical… read more here.
Keywords: timolol; treatment; clinical trials; rocket ... See more keywords
Enhanced cutaneous Rock2 expression as a marker of Rho Kinase pathway activation in autoimmune disease and Kohlemeier-Degos disease.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2019.151414
Abstract: The small guanosine triphosphatase Rho and its target Rho kinase are involved in a heterogeneous spectrum of cellular activities, many of which are integral to cytoskeletal organization. Furthermore, the Rho kinases result in NF kappa… read more here.
Keywords: rock2; degos disease; disease; autoimmune disease ... See more keywords
Rho-kinase inhibitor attenuates airway mucus hypersecretion and inflammation partly by downregulation of IL-13 and the JNK1/2-AP1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.072
Abstract: We measured the effect of Rho-kinase on inflammation and mucus hypersecretion in the airways of mouse models of asthma. Additionally, we aimed to determine if these effects were the result of JNK 1/2-AP1 pathway inhibition.We… read more here.
Keywords: kinase; inflammation; jnk1; kinase inhibitor ... See more keywords
The role of Rho-kinase and calcium ions in constriction triggered by ET-1.
Sign Up to like & getrecommendations! Published in 2018 at "Microvascular research"
DOI: 10.1016/j.mvr.2018.05.002
Abstract: Endothelin-1 (ET-1) is one of the key factors regulating tension of smooth muscles in blood vessels. It is believed that ET-1 plays an important role in pathogenesis of hypertension, and cardiovascular diseases; therefore, research in… read more here.
Keywords: calcium; constriction triggered; rho kinase; calcium ions ... See more keywords
Mechanopharmacology of Rho-kinase antagonism in airway smooth muscle and potential new therapy for asthma.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104995
Abstract: The principle of mechanopharmacology of airway smooth muscle (ASM) is based on the premise that physical agitation, such as pressure oscillation applied to an airway, is able to induce bronchodilation by reducing contractility and softening… read more here.
Keywords: mechanopharmacology; muscle; smooth muscle; rho kinase ... See more keywords
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00474
Abstract: The Rho kinase (ROCK) pathway is implicated in the pathogenesis of several conditions, including neurological diseases. In Huntington's disease (HD), ROCK is implicated in mutant huntingtin (HTT) aggregation and neurotoxicity, and members of the ROCK… read more here.
Keywords: rock; huntington disease; rho kinase; kinase ... See more keywords
Antenatal/early postnatal hypothyroidism increases the contribution of Rho-kinase to contractile responses of mesenteric and skeletal muscle arteries in adult rats
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Research"
DOI: 10.1038/s41390-018-0029-5
Abstract: BackgroundMaternal thyroid deficiency can increase Rho-kinase procontractile influence in arteries of 2-week-old progeny. Here we hypothesized that augmented role of Rho-kinase persists in arteries from adult progeny of hypothyroid rats.MethodsDams were treated with 6-propyl-2-thiouracil (PTU)… read more here.
Keywords: con; kinase; contractile responses; rho kinase ... See more keywords