Biochemical Assays to Detect Activation of Small GTPases Rho, Rac, and Cdc42 during Morphogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2035-9_5
Abstract: Wnt/Frizzled (Fz) signaling controls developmental, physiological, and pathological processes through several distinct pathways. Wnt/Fz activation of the small GTPases Rho, Rac, and Cdc42, is one key mechanism that regulates cell polarity and migration during vertebrate… read more here.
Keywords: activation small; rac cdc42; small gtpases; rho rac ... See more keywords
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20220103
Abstract: The development of resistance and the activation of bypass pathway signalling represents a major problem for the clinical application of protein kinase inhibitors. While investigating the effect of either a c-Rel deletion or RelAT505A phosphosite… read more here.
Keywords: pi3k; inhibitor; chk1 inhibitor; myc ... See more keywords