Schwann cell‐specific RhoA knockout accelerates peripheral nerve regeneration via promoting Schwann cell dedifferentiation
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24365
Abstract: Our previous studies indicated that RhoA knockdown or inhibition could alleviate the proliferation, migration, and differentiation of Schwann cells. However, the role of RhoA in Schwann cells during nerve injury and repair is still unknown.… read more here.
Keywords: schwann cells; schwann; nerve; rhoa ... See more keywords
C3 Transferase Gene Therapy for Continuous RhoA Inhibition.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8612-5_19
Abstract: The identification of RhoA inhibition as a therapeutic target in neurodegenerative diseases and traumatic central nervous system (CNS) injuries has introduced a need to develop tools that effectively modulate intracellular RhoA-dependent signaling. In neurons, the… read more here.
Keywords: rhoa inhibition; gene therapy; transferase; rhoa ... See more keywords
RhoA protects the podocytes against high glucose-induced apoptosis through YAP and plays critical role in diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.204
Abstract: BACKGROUND Podocyte apoptosis is important mechanism that leading to proteinuria in Diabetic nephropathy (DN), but the underling mechanisms that cause podocyte apoptosis in DN are not very clear. We have recently demonstrated that RhoA, a… read more here.
Keywords: podocyte apoptosis; rhoa; apoptosis; diabetic nephropathy ... See more keywords
Regulation of glucose transport by RhoA in 3T3-L1 adipocytes and L6 myoblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.09.083
Abstract: RhoA is a key player in actin cytoskeleton reorganization and exerts most of its effect through the RhoA-ROCKs signaling pathway. Although recent studies have stressed the roles of ROCKs as regulators of glucose metabolism, little… read more here.
Keywords: insulin; rhoa; transport; 3t3 adipocytes ... See more keywords
Hydrogen treatment prevents lipopolysaccharide-induced pulmonary endothelial cell dysfunction through RhoA inhibition.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.11.101
Abstract: BACKGROUND Pulmonary microvascular endothelial cells (PMVECs) are initial targets of sepsis-induced acute lung injury (ALI). During the apoptosis of PMVECs, tight junctions (TJ) and adherens junctions (AJ) are firstly damaged. Previous studies have suggested hydrogen… read more here.
Keywords: rhoa; hydrogen; treatment; dysfunction ... See more keywords
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.022
Abstract: The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development.… read more here.
Keywords: rhoa; disease; fret biosensor; normal tissue ... See more keywords
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107796
Abstract: Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia activation,… read more here.
Keywords: microglia; rhoa; neurodegeneration; physiology ... See more keywords
Spatiotemporal Regulation of RhoA during Cytokinesis
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.03.045
Abstract: The active form of the small GTPase RhoA is necessary and sufficient for formation of a cytokinetic furrow in animal cells. Despite the conceptual simplicity of the process, the molecular mechanisms that control it are… read more here.
Keywords: spatiotemporal regulation; rhoa; cytokinesis; regulation rhoa ... See more keywords
RhoA Controls Axon Extension Independent of Specification in the Developing Brain
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2019.09.040
Abstract: The specification of an axon and its subsequent outgrowth are key steps during neuronal polarization, a prerequisite to wire the brain. The Rho-guanosine triphosphatase (GTPase) RhoA is believed to be a central player in these… read more here.
Keywords: rhoa; microscopy; extension; brain ... See more keywords
RhoA regulates Schwann cell differentiation through JNK pathway
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.06.013
Abstract: Abstract RhoA is a small GTPase that regulates many functions of mammalian cells via actin reorganization. Lots of studies uncovered that its activation acts as a major negative regulator of neurite extension, and inhibition of… read more here.
Keywords: schwann cell; differentiation; jnk pathway; rhoa ... See more keywords
Identification of a novel RhoA gene in the sea cucumber Apostichopus japonicus and its immune regulatory function via interacting with miR-2012-5p.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.01.176
Abstract: RhoA (Ras homolog A) protein is a representative member of the Rho GTPase family and is involved in various cellular processes. The function of RhoA in sea cucumbers is unclear. In this study, we hypothesized… read more here.
Keywords: sea; mir 2012; rhoa; apostichopus japonicus ... See more keywords