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   Articles with "rhoa rock" as a keyword



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Vitamin D attenuates myocardial ischemia–reperfusion injury by inhibiting inflammation via suppressing the RhoA/ROCK/NF‐ĸB pathway

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recommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"

DOI: 10.1002/bab.1797

Abstract: The aim of this study was to investigate the protective effects of vitamin D (VD) against myocardial ischemia–reperfusion (I/R) injury in hearts. An I/R injury model was induced by left coronary artery ligation in Sprague‐Dawley… read more here.

Keywords: injury; myocardial ischemia; rhoa rock; rock pathway ... See more keywords
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Microindentation of Fluid-Filled Cellular Domes Reveals the Contribution of RhoA-ROCK Signaling to Multicellular Mechanics.

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recommendations! Published in 2022 at "Small"

DOI: 10.1002/smll.202200883

Abstract: Cellular mechanics encompass both mechanical properties that resist forces applied by the external environment and internally generated forces applied at the location of cell-cell and cell-matrix junctions. Here, the authors demonstrate that microindentation of cellular… read more here.

Keywords: rock signaling; cell; microindentation; mechanics ... See more keywords
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ROCK inhibitor attenuates carbon blacks‐induced pulmonary fibrosis in mice via Rho/ROCK/NF‐kappa B pathway

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recommendations! Published in 2021 at "Environmental Toxicology"

DOI: 10.1002/tox.23135

Abstract: Exposure to carbon blacks (CBs) has been associated with the progression of pulmonary fibrosis, whereas the mechanism is still not clear. We therefore aimed to investigate the effect of RhoA/ROCK pathway on pulmonary fibrosis caused… read more here.

Keywords: carbon blacks; pathway; pulmonary fibrosis; rhoa rock ... See more keywords
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Necroptosis and RhoA/ROCK pathways: molecular targets of Nesfatin-1 in cardioprotection against myocardial ischemia/reperfusion injury in a rat model.

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recommendations! Published in 2021 at "Molecular biology reports"

DOI: 10.1007/s11033-021-06289-x

Abstract: Nesfatin-1 as a new energy-regulating peptide has been known to display a pivotal role in modulation of cardiovascular functions and protection against ischemia/reperfusion injury. However, the detailed knowledge about molecular mechanisms underlying this protection has… read more here.

Keywords: ischemia reperfusion; injury; necroptosis; rhoa rock ... See more keywords
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Selenium Deficiency Affects Uterine Smooth Muscle Contraction Through Regulation of the RhoA/ROCK Signalling Pathway in Mice

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recommendations! Published in 2019 at "Biological Trace Element Research"

DOI: 10.1007/s12011-019-01677-8

Abstract: Selenium (Se) is considered one of the essential micronutrients for humans and animals, and its effects on physiological functions are multifaceted. In the present study, we investigated the effects of Se deficiency on uterine smooth… read more here.

Keywords: contraction; smooth muscle; rhoa rock; uterine smooth ... See more keywords
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Cobalt chloride induces RhoA/ROCK activation and remodeling effect in H9c2 cardiomyoblasts: Involvement of PI3K/Akt and MAPK pathways.

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recommendations! Published in 2017 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2017.04.013

Abstract: Chronic heart failure is a serious complication of myocardial infarction, one of the major causes of death worldwide that often leads to adverse cardiac hypertrophy and poor prognosis. Hypoxia-induced cardiac tissue remodeling is considered an… read more here.

Keywords: akt mapk; h9c2; rhoa rock; pi3k akt ... See more keywords
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EphA2 antagonism alleviates LPS-induced acute lung injury via Nrf2/HO-1, TLR4/MyD88 and RhoA/ROCK pathways.

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recommendations! Published in 2019 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2019.04.008

Abstract: Eph receptor tyrosine kinases have a wide range of biological functions and have gradually been recognized increasingly as key regulators of inflammation and injury diseases. Although previous studies suggested that EphA2 receptor may be involved… read more here.

Keywords: tlr4 myd88; lps induced; epha2 antagonism; rhoa rock ... See more keywords

ANGPTL7 is transcriptionally regulated by SP1 and modulates glucocorticoid-induced cross-linked actin networks in trabecular meshwork cells via the RhoA/ROCK pathway

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recommendations! Published in 2022 at "Cell Death Discovery"

DOI: 10.1038/s41420-022-00847-3

Abstract: Glaucoma is one of the leading causes of worldwide irreversible blindness. Lowering elevated intraocular pressure (IOP) is currently the only effective approach for controlling the progress of glaucoma. Angiopoietin-like 7 (ANGPTL7) takes a key part… read more here.

Keywords: clan formation; angptl7; rhoa rock; formation ... See more keywords
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RhoA/ROCK Signaling Regulates TGF-β1-Induced Fibrotic Effects in Human Pterygium Fibroblasts through MRTF-A.

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recommendations! Published in 2021 at "Current eye research"

DOI: 10.1080/02713683.2021.1962363

Abstract: PURPOSE The overexpression of transforming growth factor-beta1 (TGF-β1) after surgical excision often leads to excessive fibrosis, indicating the recurrence of pterygium. The aims of the present in vitro study were to investigate the role of… read more here.

Keywords: pterygium; rock signaling; tgf induced; rhoa rock ... See more keywords
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Rotenone inhibits axonogenesis via an Lfc/RhoA/ROCK pathway in cultured hippocampal neurons

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recommendations! Published in 2018 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.14547

Abstract: Rotenone, a broad‐spectrum insecticide, piscicide and pesticide, produces a complete and selective suppression of axonogenesis in cultured hippocampal neurons. This effect is associated with an inhibition of actin dynamics through activation of Ras homology member… read more here.

Keywords: hippocampal neurons; cultured hippocampal; rhoa; rotenone ... See more keywords
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Mechanical Stretch Promotes Macrophage Polarization and Inflammation via the RhoA-ROCK/NF-κB Pathway

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recommendations! Published in 2022 at "BioMed Research International"

DOI: 10.1155/2022/6871269

Abstract: Macrophages play an essential role in the pathogenesis of most inflammatory diseases. Recent studies have shown that mechanical load can influence macrophage function, leading to excessive and uncontrolled inflammation and even systemic damage, including cardiovascular… read more here.

Keywords: rock; rhoa rock; rhoa; rock pathway ... See more keywords