MYO3B promotes cancer progression in endometrial cancer by mediating the calcium ion-RhoA/ROCK1 signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-024-05940-x
Abstract: This study aimed to investigate the effect of MYO3B on endometrial cancer (EC) proliferation and invasion. The expression of MYO3B in EC tissues and cells was analyzed using TCGA database, immunohistochemical staining, real-time PCR, and… read more here.
Keywords: rock1 signaling; cancer; rhoa rock1; myo3b ... See more keywords
Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Neurobiology"
DOI: 10.1007/s12035-024-04058-y
Abstract: Traumatic brain injury (TBI) can lead to short-term and long-term physical and cognitive impairments, which have significant impacts on patients, families, and society. Currently, treatment outcomes for this disease are often unsatisfactory, due at least… read more here.
Keywords: traumatic brain; brain; piezo2; brain injury ... See more keywords
Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2017.1313849
Abstract: ABSTRACT Background: Recent research has shown that statins improve pulmonary arterial hypertension (PAH), but their mechanisms of action are not fully understood. This study aimed to investigate the role of RhoA/ROCK1 regulation in the therapeutic… read more here.
Keywords: simvastatin; group; rhoa rock1; pulmonary arterial ... See more keywords
Semaphorin 4C regulates ovarian steroidogenesis through RHOA/ROCK1-mediated actin cytoskeleton rearrangement.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaad010
Abstract: Semaphorins are a family of evolutionarily conserved morphogenetic molecules that were initially found to be associated with axonal guidance. Semaphorin 4C (Sema4C), a member of the fourth subfamily of semaphorins, has been demonstrated to play… read more here.
Keywords: cytoskeleton; rhoa rock1; actin cytoskeleton; ovarian steroidogenesis ... See more keywords
Trichinella spiralis serine protease mediates larval invasion of gut epithelium via binding to CK8 and activating RhoA/ROCK1 pathway
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0013725
Abstract: Background Trichinella spiralis adult worms and larvae parasitize respectively in small intestine and skeletal muscles of the same host, and larval invasion of gut mucosa is the pivotal step for T. spiralis infection. A T.… read more here.
Keywords: rock1 pathway; ck8; larval invasion; rhoa rock1 ... See more keywords
Activation of S1PR2 on macrophages and the hepatocyte S1PR2/RhoA/ROCK1/MLC2 pathway in vanishing bile duct syndrome
Sign Up to like & getrecommendations! Published in 2025 at "PLOS ONE"
DOI: 10.1371/journal.pone.0317568
Abstract: Immunologic bile duct destruction is a pathogenic condition associated with vanishing bile duct syndrome (VBDS) after liver transplantation and hematopoietic stem-cell transplantation. As the bile acid receptor sphingosine 1-phosphate receptor 2 (S1PR2) plays a critical… read more here.
Keywords: bile canaliculi; s1pr2; rhoa rock1; bile duct ... See more keywords
Schisandrin B inhibits tumor progression of hepatocellular carcinoma by targeting the RhoA/ROCK1 pathway
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-23-87
Abstract: Background Schisandrin B (Sch. B) performs various pharmacological properties, including anticancer activities. However, the pharmacological mechanisms of Sch. B in hepatocellular carcinoma (HCC) are not fully elucidated. We investigated the impact and mechanism on progression… read more here.
Keywords: cell; rhoa rock1; sch; group ... See more keywords
Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways
Sign Up to like & getrecommendations! Published in 2019 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s191617
Abstract: Aim To testify the hypothesis that endostatin exerts antifibrotic effects in hepatic stellate cells (HSCs) by modulating RhoA (ras homolog gene family, member A)/ROCK 1 (Rho-associated protein kinase 1) signal pathways. Materials and methods HSCs-T6… read more here.
Keywords: hscs; signal pathways; group; rhoa rock1 ... See more keywords
SLIT3 promotes cardiac fibrosis and differentiation of cardiac fibroblasts by RhoA/ROCK1 signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2024.73812.16044
Abstract: Objective(s): Slit guidance ligand 3 (SLIT3) has been identified as a potential therapeutic regulator against fibroblast activity and fibrillary collagen production in an autocrine manner. However, this research aims to investigate the potential role of… read more here.
Keywords: cardiac fibroblasts; slit3; rhoa rock1; cardiac fibrosis ... See more keywords
Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00431
Abstract: Background Studies have shown that both NOX4 and RhoA play essential roles in fibrosis and that they regulate each other. In lung fibrosis, NOX4/ROS is located upstream of the RhoA/ROCK1 signaling pathway, and the two… read more here.
Keywords: signaling pathways; fibrosis; rhoa rock1; nox4 ros ... See more keywords
Poria cocos Ethanol Extract Restores MK-801-Induced Cytoskeleton Regulation in Neuro2A and IMR-32 Cells and Locomotor Hyperactivity in C57BL/6 Mice by Modulating the Rho Signaling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb47050312
Abstract: Poria cocos extract attenuates MK-801-induced hyperactivity via RhoA/ROCK1 pathway modulation in mice. Background/Objectives: Poria cocos (P. cocos), a traditional East Asian medicinal mushroom, serves as a medicine and nutritional supplement, has been used to improve… read more here.
Keywords: mice; poria cocos; rhoa rock1; 801 induced ... See more keywords