Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2017.1313849
Abstract: ABSTRACT Background: Recent research has shown that statins improve pulmonary arterial hypertension (PAH), but their mechanisms of action are not fully understood. This study aimed to investigate the role of RhoA/ROCK1 regulation in the therapeutic… read more here.
Keywords: simvastatin; group; rhoa rock1; pulmonary arterial ... See more keywords
Semaphorin 4C regulates ovarian steroidogenesis through RHOA/ROCK1-mediated actin cytoskeleton rearrangement.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaad010
Abstract: Semaphorins are a family of evolutionarily conserved morphogenetic molecules that were initially found to be associated with axonal guidance. Semaphorin 4C (Sema4C), a member of the fourth subfamily of semaphorins, has been demonstrated to play… read more here.
Keywords: cytoskeleton; rhoa rock1; actin cytoskeleton; ovarian steroidogenesis ... See more keywords
Schisandrin B inhibits tumor progression of hepatocellular carcinoma by targeting the RhoA/ROCK1 pathway
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-23-87
Abstract: Background Schisandrin B (Sch. B) performs various pharmacological properties, including anticancer activities. However, the pharmacological mechanisms of Sch. B in hepatocellular carcinoma (HCC) are not fully elucidated. We investigated the impact and mechanism on progression… read more here.
Keywords: cell; rhoa rock1; sch; group ... See more keywords
Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways
Sign Up to like & getrecommendations! Published in 2019 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s191617
Abstract: Aim To testify the hypothesis that endostatin exerts antifibrotic effects in hepatic stellate cells (HSCs) by modulating RhoA (ras homolog gene family, member A)/ROCK 1 (Rho-associated protein kinase 1) signal pathways. Materials and methods HSCs-T6… read more here.
Keywords: hscs; signal pathways; group; rhoa rock1 ... See more keywords
Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells
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DOI: 10.3389/fphar.2019.00431
Abstract: Background Studies have shown that both NOX4 and RhoA play essential roles in fibrosis and that they regulate each other. In lung fibrosis, NOX4/ROS is located upstream of the RhoA/ROCK1 signaling pathway, and the two… read more here.
Keywords: signaling pathways; fibrosis; rhoa rock1; nox4 ros ... See more keywords