Cubosomes enhance drug permeability across the blood-brain barrier in zebrafish.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120411
Abstract: We investigated the potential of a self-assembled lipid nanocarrier, cubosomes, to improve delivery of incorporated cargo to the brain in vivo in zebrafish. Cubosomes were formulated with the surfactants Pluronic F68 or Pluronic F127 or… read more here.
Keywords: rhob; barrier; zebrafish cubosomes; drug ... See more keywords
RhoB induces the production of proinflammatory cytokines in TLR‐triggered macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.04.015
Abstract: HighlightsTLR agonists (LPS, CpG, poly(I:C)) induce RhoB expression in macrophages.RhoB increases the production of proinflammatory mediators in macrophages upon TLR agonists stimulation.RhoB induces LPS‐initiated signaling pathways, including phosphorylation of Btk, I&kgr;B&agr;, JNK, Erk and p38… read more here.
Keywords: rhob; rhob induces; macrophages rhob; tlr triggered ... See more keywords
Targeted Quantitative Proteomics Revealed Arsenite-induced Proteasomal Degradation of RhoB in Fibroblast Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00155
Abstract: Arsenic is a toxicant widely present in the environment. Previous epidemiological and animal studies support that arsenic exposure is associated with elevated incidences of lung and skin cancers. Therefore, it is important to understand the… read more here.
Keywords: rhob; exposure; fibroblast cells; proteasomal degradation ... See more keywords
RhoB controls the Rab11-mediated recycling and surface reappearance of LFA-1 in migrating T lymphocytes
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aai8629
Abstract: Imaging analysis reveals a mechanism for the integrin recycling required to maintain T cell migration. Recycling integrins T cells must rapidly migrate along endothelial cell surfaces and transmigrate to reach sites of infection and inflammation… read more here.
Keywords: rhob; lfa; surface; adhesion ... See more keywords
Involvement of small G protein RhoB in the regulation of proliferation, adhesion and migration by dexamethasone in osteoblastic cells
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0174273
Abstract: Long-term exposure to therapeutic doses of glucocorticoids (GCs) results in bone remodeling, which frequently causes osteoporosis and fracture healing retardation because of the abnormality of osteoblastic proliferation and differentiation. The mechanisms of GCs’ effect on… read more here.
Keywords: rhob; protein; dex; adhesion ... See more keywords
Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13205144
Abstract: Simple Summary Glioblastoma multiforme (GBM) and metastatic triple-negative breast cancer (TNBC) with PTEN mutations are associated with brain tumor spreading and poor patient outcomes. GBM, and possibly TNBC, migrate on axons and blood vessels to… read more here.
Keywords: rhob; cell; gbm; tnbc ... See more keywords
RhoB: Team Oncogene or Team Tumor Suppressor?
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.3390/genes9020067
Abstract: Although Rho GTPases RhoA, RhoB, and RhoC share more than 85% amino acid sequence identity, they play very distinct roles in tumor progression. RhoA and RhoC have been suggested in many studies to contribute positively… read more here.
Keywords: rhob; team; tumor suppressor; rhob team ... See more keywords