Proteomic approach to explore the role of Rho-related BTB Domain Containing 1 (RhoBTB1)-Cullin-3 (CUL-3) pathway in identifying potential therapeutic candidates in cardioprotection
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5730553
Abstract: Protein-protein interaction studies have contributed enormously to understand the fundamentals of human impairments including cardiovascular diseases. We previously identified Phosphodiesterase 5 (PDE5) as an interacting partner of RhoBTB1. The latter can function as an adapter… read more here.
Keywords: pde5; rhobtb1; rhobtb1 cul; cul pathway ... See more keywords
Abstract MP23: Vascular Smooth Muscle Rho-related Btb Domain Containing Protein 1 In Hypertension And Arterial Stiffness
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension"
DOI: 10.1161/hyp.76.suppl_1.mp23
Abstract: Rho-related BTB domain containing protein 1 (RhoBTB1) is a transcriptional target of peroxisome proliferator activated receptor γ (PPARγ), but its physiological and molecular function in blood pressure (BP) control remains unclear. We showed that aortic… read more here.
Keywords: arterial stiffness; ism cre; rhobtb1; mice ... See more keywords
RhoBTB1 reverses established arterial stiffness in angiotensin II–induced hypertension by promoting actin depolymerization
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.158043
Abstract: Arterial stiffness predicts cardiovascular disease and all-cause mortality, but its treatment remains challenging. Mice treated with angiotensin II (Ang II) develop hypertension, arterial stiffness, vascular dysfunction, and a downregulation of Rho-related BTB domain–containing protein 1… read more here.
Keywords: vascular dysfunction; rhobtb1; hypertension; stiffness ... See more keywords
The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B
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DOI: 10.1186/s12885-017-3138-3
Abstract: BackgroundRhoBTB1 and 2 are atypical members of the Rho GTPase family of signaling proteins. Unlike other Rho GTPases, RhoBTB1 and 2 undergo silencing or mutation in a wide range of epithelial cancers; however, little is… read more here.
Keywords: breast cancer; expression; rhobtb1; cancer ... See more keywords