Comparative α-glucosidase and α-amylase inhibition studies of rhodanine–pyrazole conjugates and their simple rhodanine analogues
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2272-z
Abstract: Novel rhodanine–pyrazole conjugates (6a–i) and their simple rhodanine analogues (8a–e) were prepared and comparatively screened for their antidiabetic activities against enzymatic targets, α-glucosidase and α-amylase. As expected, the molecular hybrids exhibited significantly greater inhibitory activity… read more here.
Keywords: rhodanine; simple rhodanine; rhodanine pyrazole; conjugates simple ... See more keywords
A Fluorescent Turn-On Carbazole-Rhodanine Based Sensor for Detection of Ag+ Ions and Application in Ag+ Ions Imaging in Cancer Cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fluorescence"
DOI: 10.1007/s10895-018-2312-6
Abstract: Carbazole – Rhodanine conjugate is an effective fluorescent host for silver ions through fluorometric transformation from green to red color with a hyperchromic emission. An intramolecular charge transfer process derived from carbazole towards rhodanine favors… read more here.
Keywords: rhodanine; detection; fluorescent; carbazole rhodanine ... See more keywords
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104507
Abstract: In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3'-oxindoles]. They were obtained by one-pot… read more here.
Keywords: rhodanine; novel amylase; amylase inhibitors; study ... See more keywords
Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives.
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DOI: 10.1039/c7md00173h
Abstract: A series of novel thiazolidine-2,4-dione or rhodanine derivatives (5a-5k, 6a-6k) were synthesized and evaluated for their α-glucosidase inhibitory activity. The majority of compounds exhibited potent inhibitory activity in the range of 5.44 ± 0.13 to… read more here.
Keywords: dione rhodanine; rhodanine; thiazolidine dione; molecular docking ... See more keywords
A New Synthesis Strategy for Rhodanine and Its Derivatives
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DOI: 10.1055/a-1485-5925
Abstract: Rhodanine and its derivatives have been known as privileged structures in pharmacological research because of their wide spectrum of biological activities, but the synthesis method of rhodanine skeleton is limited. In this paper, not only… read more here.
Keywords: new synthesis; synthesis strategy; rhodanine derivatives; rhodanine ... See more keywords
Discovery of Cinnamylidene Derivative of Rhodanine with High Anthelmintic Activity against Rhabditis sp.
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DOI: 10.3390/molecules27072155
Abstract: The treatment of parasitic infections requires the application of chemotherapy. In view of increasing resistance to currently in-use drugs, there is a constant need to search for new compounds with anthelmintic activity. A series of… read more here.
Keywords: rhodanine; rhabditis; discovery cinnamylidene; activity ... See more keywords
Synthesis, Crystal Structures, Lipophilic Properties and Antimicrobial Activity of 5-Pyridylmethylidene-3-rhodanine-carboxyalkyl Acids Derivatives
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DOI: 10.3390/molecules27133975
Abstract: The constant increase in the resistance of pathogenic bacteria to the commonly used drugs so far makes it necessary to search for new substances with antibacterial activity. Taking up this challenge, we obtained a series… read more here.
Keywords: rhodanine; synthesis crystal; structures lipophilic; crystal structures ... See more keywords