Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives.
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DOI: 10.1039/c7md00173h
Abstract: A series of novel thiazolidine-2,4-dione or rhodanine derivatives (5a-5k, 6a-6k) were synthesized and evaluated for their α-glucosidase inhibitory activity. The majority of compounds exhibited potent inhibitory activity in the range of 5.44 ± 0.13 to… read more here.
Keywords: dione rhodanine; rhodanine; thiazolidine dione; molecular docking ... See more keywords
A New Synthesis Strategy for Rhodanine and Its Derivatives
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DOI: 10.1055/a-1485-5925
Abstract: Rhodanine and its derivatives have been known as privileged structures in pharmacological research because of their wide spectrum of biological activities, but the synthesis method of rhodanine skeleton is limited. In this paper, not only… read more here.
Keywords: new synthesis; synthesis strategy; rhodanine derivatives; rhodanine ... See more keywords
Synthesis and antimicrobial activity of novel thienopyrimidine linked rhodanine derivatives
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DOI: 10.1139/cjc-2018-0220
Abstract: This work presents the preparation of a new series of N-(substituted phenyl)-2-(4-oxo-5-(4-(thieno[2,3-d]-pyrimidin-4-yloxy)benzylidene)-2-thioxothiazolidin-3-yl)acetamide derivatives (8a–8l). A condensation reaction of thienopyrimidin-2-thioxothiazolidin-4-one derivative (5) with various 2-chloro-N-phenylacetamides (7a–7l) was employed to afford the new thienopyrimidine tagged rhodanine derivatives… read more here.
Keywords: thienopyrimidine; antimicrobial activity; activity novel; synthesis antimicrobial ... See more keywords
Electrochemistry of Rhodanine Derivatives as Model for New Colorimetric and Electrochemical Azulene Sensors for the Detection of Heavy Metal Ions
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DOI: 10.3390/sym15030752
Abstract: Rhodanine (R) is a heterocycle having complexing properties for heavy metal (HM) ions. Considering the similar electron-donating character of diethylaminobenzene and azulene, electrochemical characterization of (Z)-5-(azulen-1-ylmethylene)-2-thioxo-thiazolidin-4-one (R1) and 5-(4 diethylamino-benzylidene)-2-thioxo-thiazolidin-4-one (R2) was performed to establish… read more here.
Keywords: metal ions; heavy metal; electrochemistry; rhodanine derivatives ... See more keywords