Blood signatures for second stage human African trypanosomiasis: a transcriptomic approach
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DOI: 10.1186/s12920-020-0666-5
Abstract: Background Rhodesiense sleeping sickness is caused by infection with T. b rhodesiense parasites resulting in an acute disease that is fatal if not treated in time. The aim of this study was to understand the… read more here.
Keywords: second stage; infection; blood; rhodesiense ... See more keywords
Plasma Neuron-Specific Enolase is not a reliable biomarker for staging Trypanosoma brucei rhodesiense sleeping sickness patients
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DOI: 10.1186/s13104-022-05981-w
Abstract: Objective Currently, the only available staging criterion for T. b. rhodesiense requires a lumber puncture to collect and later examine cerebrospinal fluid (CSF). This study examined the potential of plasma Neuron-Specific Enolase (NSE) in discriminating… read more here.
Keywords: stage patients; plasma neuron; specific enolase; neuron specific ... See more keywords
Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response
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DOI: 10.3390/ijms24010656
Abstract: The protozoan Trypanosoma brucei rhodesiense causes Human African Trypanosomiasis, also known as sleeping sickness, and penetrates the central nervous system, leading to meningoencephalitis. The Cathepsin L-like cysteine peptidase of T. b. rhodesiense has been implicated… read more here.
Keywords: rhodesiense; icp; trypanosoma brucei; cysteine peptidase ... See more keywords
Haemoparasitic Infections in Cattle from a Trypanosoma brucei Rhodesiense Sleeping Sickness Endemic District of Eastern Uganda
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DOI: 10.3390/tropicalmed5010024
Abstract: We carried out a baseline survey of cattle in Kaberamaido district, in the context of controlling the domestic animal reservoir of Trypanosoma brucei rhodesiense human African trypanosomiasis (rHAT) towards elimination. Cattle blood was subjected to… read more here.
Keywords: eastern uganda; brucei rhodesiense; district; trypanosoma brucei ... See more keywords