An experimental comparison of human and bovine rhodopsin provides insight into the molecular basis of retinal disease
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12637
Abstract: Rhodopsin is the visual pigment that mediates dim‐light vision in vertebrates and is a model system for the study of retinal disease. The majority of rhodopsin experiments are performed using bovine rhodopsin; however, recent evidence… read more here.
Keywords: bovine rhodopsin; retinal disease; rhodopsin; experimental comparison ... See more keywords
Characterizing variants of unknown significance in rhodopsin: A functional genomics approach
Sign Up to like & getrecommendations! Published in 2019 at "Human Mutation"
DOI: 10.1002/humu.23762
Abstract: Characterizing the pathogenicity of DNA sequence variants of unknown significance (VUS) is a major bottleneck in human genetics, and is increasingly important in determining which patients with inherited retinal diseases could benefit from gene therapy.… read more here.
Keywords: unknown significance; variants unknown; characterizing variants; rhodopsin ... See more keywords
Understanding the Rhodopsin Worldview Through Atomic Force Microscopy (AFM): Structure, Stability, and Activity Studies.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical record"
DOI: 10.1002/tcr.202300113
Abstract: Rhodopsin is a G protein-coupled receptor (GPCR) present in the rod outer segment (ROS) of photoreceptor cells that initiates the phototransduction cascade required for scotopic vision. Due to the remarkable advancements in technological tools, the… read more here.
Keywords: structure; rhodopsin; force microscopy; microscopy ... See more keywords
Detection of misfolded rhodopsin aggregates in cells by Förster resonance energy transfer.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2018.08.007
Abstract: Rhodopsin is the light receptor in rod photoreceptor cells of the retina that plays a central role in phototransduction and rod photoreceptor cell health. Rhodopsin mutations are the leading known cause of autosomal dominant retinitis… read more here.
Keywords: aggregation; energy transfer; rster resonance; rhodopsin ... See more keywords
Measurement of Slow Spontaneous Release of 11-cis-Retinal from Rhodopsin.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2016.12.005
Abstract: The vertebrate visual photoreceptor rhodopsin (Rho) is a unique G protein-coupled receptor as it utilizes a covalently tethered inverse agonist (11-cis-retinal) as the native ligand. Previously, electrophysiological studies showed that ligand binding of 11-cis-retinal in… read more here.
Keywords: spontaneous release; cis retinal; rhodopsin; release cis ... See more keywords
The Energetics of Chromophore Binding in the Visual Photoreceptor Rhodopsin.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.05.036
Abstract: The visual photoreceptor rhodopsin is a prototypical G-protein-coupled receptor (GPCR) that stabilizes its inverse agonist ligand, 11-cis-retinal (11CR), by a covalent, protonated Schiff base linkage. In the visual dark adaptation, the fundamental molecular event after… read more here.
Keywords: kcal mol; rhodopsin; photoreceptor rhodopsin; visual photoreceptor ... See more keywords
Impact of temperature on sea bass, Dicentrarchus labrax, retina: Fatty acid composition, expression of rhodopsin and enzymes of lipid and melatonin metabolism
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.03.010
Abstract: Abstract Teleost fish are ectothermic vertebrates. Their metabolism, physiology and behavior rely on the external temperature. This study, on the retina of the sea bass Dicentrarchus labrax, reports on the impact of temperature on the… read more here.
Keywords: temperature; fatty acid; rhodopsin; abundance ... See more keywords
Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.10.023
Abstract: Abstract We produced 8 lines of transgenic (Tg) rats expressing one of two different rhodopsin mutations in albino Sprague‐Dawley (SD) rats. Three lines were generated with a proline to histidine substitution at codon 23 (P23H),… read more here.
Keywords: p23h; rhodopsin; s334ter; degeneration ... See more keywords
Identification of novel RHO homozygous mutation in Chinese autosomal recessive retinitis pigmentosa patients.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107726
Abstract: Retinitis pigmentosa (RP) is a group of genetically heterogeneous retinal diseases with more than 80 identified causative genes to date. The RHO (rhodopsin, OMIM 180380) gene mutation is a hotspot mutation worldwide and is one… read more here.
Keywords: rhodopsin; retinitis pigmentosa; rho homozygous; autosomal recessive ... See more keywords
Accelerated evolution and positive selection of rhodopsin in Tibetan loaches living in high altitude.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.10.151
Abstract: Rhodopsin (RH1), the temperature-sensitive visual pigment, attained cold adaptation by functional trade-offs between protein stability and activity. Recent studies suggested convergent selection pressures drove cold adaptation of rhodopsin in high altitude catfishes through nonparallel molecular… read more here.
Keywords: evolution; rhodopsin; selection; high altitude ... See more keywords
TAT Rhodopsin Is an Ultraviolet-Dependent Environmental pH Sensor.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00951
Abstract: In many rhodopsins, the retinal Schiff base pKa remains very high, ensuring Schiff base protonation captures visible light. Nevertheless, recently we found that TAT rhodopsin contains protonated and unprotonated forms at physiological pH. The protonated… read more here.
Keywords: rhodopsin ultraviolet; rhodopsin; ultraviolet dependent; tat rhodopsin ... See more keywords